Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | RECQL | P46063 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12380944 | 0.70 | GABRA1 (0.46) | LMNAHIF1ATSHRBLMADRA2A | |
| SCHEMBL11850416 | 0.70 | ADRB2 (0.39) | KDM4EMAPTLMNAHIF1ATSHR | |
| SCHEMBL11849763 | 0.70 | METAP2 (0.33) | ADRA2AADRA2BADRA2CADRA1AADRB2 | |
| SCHEMBL2250 | 0.69 | ADRA2A (0.61) | TDP1KDM4ERECQLMAPTLMNA | |
| SCHEMBL27750307 | 0.69 | TDP1 (0.49) | TDP1KDM4ERECQLMAPTLMNA | |
| Hydrochloric Acid SCHEMBL11842180 | 0.69 | ADRB2 (0.38) | TDP1KDM4EMAPTLMNAHIF1A | |
| SCHEMBL11841871 | 0.68 | ADRB2 (0.56) | TDP1LMNAHIF1ATSHRNFKB1 | |
| SCHEMBL30557720 | 0.67 | ADRA2A (0.37) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL11844944 | 0.66 | ADRB2 (0.55) | KDM4EMAPTLMNAHIF1ATSHR | |
| Hydrochloric Acid SCHEMBL11853153 | 0.65 | KDM4E (0.54) | TDP1KDM4EMAPTLMNAHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3976695-A | Halogen substituted α-(aminoalkyl)-3,4-dihydroxybenzyl alcohols | SMITHKLINE CORPORATION (US) | 1976-08-24 | — | — | US | disclosed |