Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 6/20 | 0.48 |
| ▸ | DUSP3 | P51452 | 6/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | USP28 | Q96RU2 | 1/20 | 0.39 |
| ▸ | USP25 | Q9UHP3 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29766263 | 1.00 | PTPN7 (0.48) | PTPN7DUSP3ARNR3C2KIF11 | |
| Ether SCHEMBL27547445 | 0.88 | PTPN7 (0.41) | PTPN7DUSP3ARNR3C2EPHX1 | |
| SCHEMBL27789311 | 0.84 | NR3C2 (0.46) | PTPN7DUSP3ARNR3C2KIF11 | |
| SCHEMBL698164 | 0.83 | KIF11 (0.53) | KIF11P2RX7 | |
| SCHEMBL29889972 | 0.83 | KIF11 (0.53) | KIF11P2RX7 | |
| SCHEMBL1775215 | 0.83 | RXRA (0.44) | PTPN7DUSP3KIF11IDO1 | |
| SCHEMBL10662203 | 0.83 | PTPN7 (0.47) | PTPN7DUSP3ARNR3C2KIF11 | |
| SCHEMBL6758819 | 0.82 | PTPN7 (0.38) | PTPN7DUSP3ARCYP3A4CYP2D6 | |
| Bromide SCHEMBL28322451 | 0.82 | KIF11 (0.51) | KIF11P2RX7 | |
| SCHEMBL78124 | 0.81 | NR3C2 (0.44) | PTPN7DUSP3ARNR3C2KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 223 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183239-B1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2012-08-22 | — | — | EP | claimed |
| US-20120190674-A1 | SULFONAMIDES AS TRPM8 MODULATORS | BRANUM SHAWN T (US) | 2012-07-26 | — | — | US | claimed |
| EP-2183239-A1 | SULFONAMIDES AS TRPM8 MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2010-05-12 | — | — | EP | claimed |
| US-20090264474-A1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-10-22 | — | — | US | claimed |
| WO-2009012430-A1 | SULFONAMIDES AS TRPM8 MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-01-22 | — | — | WO | claimed |
| CN-119431371-B | Beta-carbolin 3,6, 9-modified derivative and preparation method and application thereof | 沈阳药科大学 | 2026-05-19 | — | — | CN | disclosed |
| US-20250163029-A1 | PYRIDONE OR PYRIMIDONE DERIVATIVE AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2025-05-22 | — | — | US | disclosed |
| CN-119431371-A | Beta-carbolin 3,6, 9-modified derivative and preparation method and application thereof | 沈阳药科大学 | 2025-02-14 | — | — | CN | disclosed |
| US-20240270695-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS | J. MICHAEL BISHOP INSTITUTE OF CANCER RESEARCH (CN) | 2024-08-15 | — | — | US | disclosed |
| CN-118344360-A | 1-Phenyl-tetrahydro-beta-carboline derivative and preparation method and application thereof | 寒武智元(南京)生物医药科技有限公司 | 2024-07-16 | — | — | CN | disclosed |
| US-20240199587-A1 | HETEROCYCLIC COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2024-06-20 | — | — | US | disclosed |
| CN-117843515-A | Aromatic amino acid derivative as LAT1 inhibitor and preparation method and application thereof | 中国药科大学 | 2024-04-09 | — | — | CN | disclosed |
| WO-2000071536-A1 | HETEROARYLOXYPYRIMIDINE INSECTICIDES AND ACARICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-11-30 | — | — | WO | disclosed |
| US-6150526-A | Piperidine derivative having renin inhibiting activity | HOFFMANN-LA ROCHE INC. (US) | 2000-11-21 | — | — | US | disclosed |
| WO-2000049001-A2 | PHENOXY-, PHENYLTHIO-, PHENYLAMINO-, BENZYLOXY-, BENZYLTHIO- OR BENZYLAMINOPYRIMIDINE INSECTIDICES AND ACARICIDES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-08-24 | — | — | WO | disclosed |
| EP-1020441-A1 | N-HETEROCYCLIC METHYLPROPYLAMINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND GERMICIDES | KUREHA KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 2000-07-19 | — | — | EP | disclosed |
| US-6051712-A | PREVENTION OF HIGH BLOOD PRESSURE AND CARDIAC INSUFFICIENCY, AS WELL AS GLAUCOMA, CARDIAC INFARCT, KIDNEY INSUFFICIENCY AND RESTENOSIS | HOFFMANN-LA ROCHE INC. (US) | 2000-04-18 | — | — | US | disclosed |
| CN-1202152-A | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 1998-12-16 | — | — | CN | disclosed |
| EP-0863875-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997009311-A1 | NEW 4-(OXYALKOXYPHENYL)-3-OXY-PIPERIDINES FOR TREATING HEART AND KIDNEY INSUFFICIENCY | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240270695-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING DISORDERS | CYP27A1, PNLIP, GOT2 | PTPN7 3469/4885DUSP3 3189/4885AR 577/4885 |
| US-20240199587-A1 | HETEROCYCLIC COMPOUNDS | CYP1B1, CYP1A1, CYP4B1 | PTPN7 3193/4885DUSP3 4871/4885AR 736/4885 |
| US-20120190674-A1 | SULFONAMIDES AS TRPM8 MODULATORS | TRPM8, TRPM5, TRPM2 | PTPN7 3374/4885DUSP3 3287/4885AR 1959/4885 |
| US-20250163029-A1 | PYRIDONE OR PYRIMIDONE DERIVATIVE AND APPLICATION THEREOF | DPYD, PNPO, TYMP | PTPN7 1018/4885DUSP3 1650/4885AR 3866/4885 |
| US-20090264474-A1 | SULFONAMIDES AS TRPM8 MODULATORS | TRPM8, TRPM5, TRPM2 | PTPN7 3374/4885DUSP3 3287/4885AR 1959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.