Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 1.00 |
| ▸ | HPGD | P15428 | 6/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.75 |
| ▸ | MAPT | P10636 | 5/20 | 0.68 |
| ▸ | TSHR | P16473 | 7/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8802200 | 0.84 | TSHR (0.84) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6835903 | 0.82 | ALDH1A1 (0.70) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3642839 | 0.79 | MAPT (0.88) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6426650 | 0.76 | KMT2A (0.69) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15528812 | 0.75 | MAPK1 (0.71) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2058331 | 0.75 | ALDH1A1 (0.68) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13701152 | 0.74 | RAB9A (0.74) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13167004 | 0.73 | ALDH1A1 (1.00) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL414754 | 0.73 | MEN1 (0.83) | ALDH1A1HPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL2028671 | 0.73 | DHODH (0.86) | ALDH1A1RAB9ANPC1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8785499-B2 | Targeting NAD biosynthesis in bacterial pathogens | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2014-07-22 | — | — | US | disclosed |
| US-20120190708-A1 | TARGETING NAD BIOSYNTHESIS IN BACTERIAL PATHOGENS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2012-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120190708-A1 | TARGETING NAD BIOSYNTHESIS IN BACTERIAL PATHOGENS | NAMPT, NAPRT, NADK | ALDH1A1 1536/4885HPGD 66/4885RAB9A 2191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.