Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.38 |
| ▸ | ARG1 | P05089 | 3/20 | 0.33 |
| ▸ | ARG2 | P78540 | 1/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7032911 | 1.00 | HTR1A (0.44) | HTR1AHTR1DHTR2AHRH1ADRA1B | |
| SCHEMBL1190924 | 1.00 | HTR1A (0.44) | HTR1AHTR1DHTR2AHRH1ADRA1B | |
| Hydrochloric Acid SCHEMBL27899317 | 0.98 | HTR1A (0.43) | HTR1AHTR1DHTR2AHRH1ADRA1B | |
| Hydrochloric Acid SCHEMBL1190265 | 0.98 | HTR1A (0.43) | HTR1AHTR1DHTR2AHRH1ADRA1B | |
| SCHEMBL10326397 | 0.94 | HTR1A (0.50) | HTR1AHTR1DHTR2AHRH1ADRA1B | |
| SCHEMBL8562869 | 0.94 | HTR1A (0.50) | HTR1AHTR1DHTR2AHRH1ADRA1B | |
| SCHEMBL10326175 | 0.94 | HTR1A (0.50) | HTR1AHTR1DHTR2AHRH1ADRA1B | |
| Hydrochloric Acid SCHEMBL11144978 | 0.93 | HTR1A (0.49) | HTR1AHTR1DHTR2AHRH1ADRA1B | |
| SCHEMBL488775 | 0.84 | HTR1A (0.45) | HTR1AHTR1DHTR2AHRH1ADRA1B | |
| SCHEMBL22507863 | 0.84 | HTR1A (0.45) | HTR1AHTR1DHTR2AHRH1ADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021070658-A1 | METHOD FOR PRODUCING CYCLOPENTANE COMPOUND, METHOD FOR PRODUCING LACTONE COMPOUND, METHOD FOR PRODUCING DIOL COMPOUND, AND COMPOUND | 国立大学法人東北大学 | 2021-04-15 | — | — | WO | disclosed |
| WO-2017017630-A1 | NOVEL BETULINIC SUBSTITUTED AMIDE DERIVATIVES AS HIV INHIBITORS | HETERO RESEARCH FOUNDATION (IN) | 2017-02-02 | — | — | WO | disclosed |
| EP-2438989-B1 | USE OF ASYMMETRIC HYDROGENATION CATALYST | TAKASAGO PERFUMERY CO LTD (JP) | 2016-04-13 | — | — | EP | disclosed |
| EP-2217226-B1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2015-07-22 | — | — | EP | disclosed |
| US-8716500-B2 | Method for producing five-membered ring-containing compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-05-06 | — | — | US | disclosed |
| US-8716500-B2 | Method for producing five-membered ring-containing compound | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-05-06 | — | — | US | disclosed |
| US-20140051874-A1 | METHOD FOR PRODUCING FIVE-MEMBERED RING-CONTAINING COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-02-20 | — | — | US | disclosed |
| US-20140051874-A1 | METHOD FOR PRODUCING FIVE-MEMBERED RING-CONTAINING COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2014-02-20 | — | — | US | disclosed |
| US-20130045962-A1 | PEPTIDE DEFORMYLASE INHIBITORS | GLAXOSMITHKLINE LLC | 2013-02-21 | — | — | US | disclosed |
| CN-101917981-B | Peptide deformylase inhibitors | SMITHKLINE BEECHAM CORP | 2012-11-14 | — | — | CN | disclosed |
| EP-1287001-B1 | THIOPHENE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PROD INC (US) | 2004-09-29 | — | — | EP | disclosed |
| US-20040186134-A1 | Sulfonamide lactam inhibitors of FXa and method | O'CONNOR STEPHEN P (US) | 2004-09-23 | — | — | US | disclosed |
| US-6555542-B1 | Factor Xa (FXa); useful as anticoagulants in the treatment of cardiovascular diseases associated with thrombosis | BRISTOL-MYERS SQUIBB COMPANY | 2003-04-29 | — | — | US | disclosed |
| EP-1287001-A1 | THIOPHENE DERIVATIVES USEFUL AS ANTICANCER AGENTS | Pfizer Products Inc. (US) | 2003-03-05 | — | — | EP | disclosed |
| WO-2002096361-A2 | 5-ARALKYLSULFONYL-3- (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2002-12-05 | — | — | WO | disclosed |
| US-20020042409-A1 | Thiophene derivatives useful as anticancer agents | PFIZER PRODUCTS INC. | 2002-04-11 | — | — | US | disclosed |
| WO-2001094353-A1 | THIOPHENE DERIVATIVES USEFUL AS ANTICANCER AGENTS | PFIZER PRODUCTS INC. (US) | 2001-12-13 | — | — | WO | disclosed |
| EP-0156191-B1 | CONDENSED DIAZEPINONES, PROCESS FOR THEIR PREPARATION AND MEDICAMENTS CONTAINING THESE COMPOUNDS | Dr. Karl Thomae GmbH (DE) | 1989-07-19 | — | — | EP | disclosed |
| US-4550107-A | Condensed diazepinones, their compositions and methods of use as pharmaceuticals | DR. KARL THOMAE GMBH (DE) | 1985-10-29 | — | — | US | disclosed |
| EP-0156191-A2 | Condensed diazepinones, process for their preparation and medicaments containing these compounds | Dr. Karl Thomae GmbH (DE) | 1985-10-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140051874-A1 | METHOD FOR PRODUCING FIVE-MEMBERED RING-CONTAINING COMPOUND | PTGIS, ALOX5, PTGES | HTR1A 2945/4885HTR1D 1859/4885HTR2A 3642/4885 |
| US-20130045962-A1 | PEPTIDE DEFORMYLASE INHIBITORS | PDF, DPEP1, DHPS | HTR1A 3258/4885HTR1D 2874/4885HTR2A 2761/4885 |
| US-20040186134-A1 | Sulfonamide lactam inhibitors of FXa and method | STS, SULT1E1, F8 | HTR1A 1453/4885HTR1D 2085/4885HTR2A 2765/4885 |
| US-20020042409-A1 | Thiophene derivatives useful as anticancer agents | TP53, RCC1, CCNA1 | HTR1A 2257/4885HTR1D 1059/4885HTR2A 4117/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.