Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.73 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 7/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.53 |
| ▸ | THRB | P10828 | 2/20 | 0.51 |
| ▸ | MPL | P40238 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 6/20 | 0.49 |
| ▸ | HTT | P42858 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1615338 | 1.00 | NPC1 (0.73) | NPC1RAB9AFTOKMT2AMAPT | |
| SCHEMBL29377457 | 1.00 | NPC1 (0.73) | NPC1RAB9AFTOKMT2AMAPT | |
| SCHEMBL11305364 | 0.89 | FTO (0.73) | NPC1RAB9AFTOKMT2AMAPT | |
| SCHEMBL11305360 | 0.89 | FTO (0.73) | NPC1RAB9AFTOKMT2AMAPT | |
| SCHEMBL7913514 | 0.86 | NPC1 (0.80) | NPC1RAB9AFTOKMT2AMAPT | |
| SCHEMBL8204503 | 0.86 | NPC1 (0.80) | NPC1RAB9AFTOKMT2AMAPT | |
| SCHEMBL13290672 | 0.82 | KMT2A (0.73) | NPC1RAB9AFTOKMT2AMAPT | |
| SCHEMBL14597256 | 0.82 | KMT2A (0.73) | NPC1RAB9AFTOKMT2AMAPT | |
| SCHEMBL1275967 | 0.81 | FTO (1.00) | NPC1RAB9AFTOKMT2AMAPT | |
| SCHEMBL1275966 | 0.81 | FTO (1.00) | NPC1RAB9AFTOKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9498426-B2 | Process for treating hair fibers using polysiloxane/polyurea | L'OREAL (FR) | 2016-11-22 | — | — | US | disclosed |
| US-9498426-B2 | Process for treating hair fibers using polysiloxane/polyurea | L'OREAL (FR) | 2016-11-22 | — | — | US | disclosed |
| EP-2579841-B1 | COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED WITH AN ESTER OR AMIDE RADICAL, AND AT LEAST ONE PIGMENT OR DIRECT DYE, FOR DYEING KERATIN MATERIALS | ORÉAL L (FR) | 2016-09-14 | — | — | EP | disclosed |
| US-8771376-B2 | Composition comprising at least one 2-pyrrolidone functionalized with an ester or amide radical, and at least one pigment or direct dye, for dyeing keratin materials | L'OREAL (FR) | 2014-07-08 | — | — | US | disclosed |
| US-8771376-B2 | Composition comprising at least one 2-pyrrolidone functionalized with an ester or amide radical, and at least one pigment or direct dye, for dyeing keratin materials | L'OREAL (FR) | 2014-07-08 | — | — | US | disclosed |
| US-8585779-B2 | Composition comprising at least one 2-pyrrolidone functionalized in the 4 position with a carboxylic acid or amide, and at least one direct dye or a pigment for dyeing keratin fibres | L'OREAL (FR) | 2013-11-19 | — | — | US | disclosed |
| US-20130167307-A1 | COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED IN THE 4 POSITION WITH A CARBOXYLIC ACID OR AMIDE, AND AT LEAST ONE DIRECT DYE OR A PIGMENT FOR DYEING KERATIN FIBRES | L'OREAL (FR) | 2013-07-04 | — | — | US | disclosed |
| US-20130167307-A1 | COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED IN THE 4 POSITION WITH A CARBOXYLIC ACID OR AMIDE, AND AT LEAST ONE DIRECT DYE OR A PIGMENT FOR DYEING KERATIN FIBRES | L'OREAL (FR) | 2013-07-04 | — | — | US | disclosed |
| US-20130152314-A1 | COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED WITH AN ESTER OR AMIDE RADICAL, AND AT LEAST ONE PIGMENT OR DIRECT DYE, FOR DYEING KERATIN MATERIALS | L'OREAL (FR) | 2013-06-20 | — | — | US | disclosed |
| US-20130152314-A1 | COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED WITH AN ESTER OR AMIDE RADICAL, AND AT LEAST ONE PIGMENT OR DIRECT DYE, FOR DYEING KERATIN MATERIALS | L'OREAL (FR) | 2013-06-20 | — | — | US | disclosed |
| US-20090260165-A9 | Composition comprising a compound X and A compound Y, at least one of which is a silicone, and a hydrophobic direct dye | BRUN GAELLE | 2009-10-22 | — | — | US | disclosed |
| EP-2074986-A1 | Process for treating hair fibres using polysiloxane/polyurea | L'Oréal (FR) | 2009-07-01 | — | — | EP | disclosed |
| US-20090155198-A1 | PROCESS FOR TREATING HAIR FIBERS USING POLYSILOXANE/POLYUREA | L'OREAL, S.A. (FR) | 2009-06-18 | — | — | US | disclosed |
| US-20090155198-A1 | PROCESS FOR TREATING HAIR FIBERS USING POLYSILOXANE/POLYUREA | L'OREAL, S.A. (FR) | 2009-06-18 | — | — | US | disclosed |
| US-20080184496-A1 | Composition comprising a compound X and A compound Y, at least one of which is a silicone, and a hydrophobic direct dye | L'OREAL S.A. (FR) | 2008-08-07 | — | — | US | disclosed |
| US-20080184496-A1 | Composition comprising a compound X and A compound Y, at least one of which is a silicone, and a hydrophobic direct dye | L'OREAL S.A. (FR) | 2008-08-07 | — | — | US | disclosed |
| EP-1935403-A2 | Composition containing a compound x and a compound y, at least one of which is silicone, and a hydrophobic direct dye | L'Oréal (FR) | 2008-06-25 | — | — | EP | disclosed |
| EP-1935404-A1 | Composition for dyeing keratinous fibres comprising a polysiloxane-polyurea block copolymer | L'Oréal (FR) | 2008-06-25 | — | — | EP | disclosed |
| US-20080127429-A1 | Coloring composition of keratinous fibers comprising at least one polysiloxane/polyurea block copolymer | L'OREAL S.A. (FR) | 2008-06-05 | — | — | US | disclosed |
| US-20080127429-A1 | Coloring composition of keratinous fibers comprising at least one polysiloxane/polyurea block copolymer | L'OREAL S.A. (FR) | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090155198-A1 | PROCESS FOR TREATING HAIR FIBERS USING POLYSILOXANE/POLYUREA | PUF60, POLR1C, PCBP1 | NPC1 4741/4885RAB9A 4729/4885FTO 1763/4885 |
| US-20130167307-A1 | COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED IN THE 4 POSITION WITH A CARBOXYLIC ACID OR AMIDE, AND AT LEAST ONE DIRECT DYE OR A PIGMENT FOR DYEING KERATIN FIBRES | KRT18, ADH1A, ADH1C | NPC1 4076/4885RAB9A 4089/4885FTO 1180/4885 |
| US-20080127429-A1 | Coloring composition of keratinous fibers comprising at least one polysiloxane/polyurea block copolymer | KRT18, PUF60, VIM | NPC1 4852/4885RAB9A 4677/4885FTO 3544/4885 |
| US-20130152314-A1 | COMPOSITION COMPRISING AT LEAST ONE 2-PYRROLIDONE FUNCTIONALIZED WITH AN ESTER OR AMIDE RADICAL, AND AT LEAST ONE PIGMENT OR DIRECT DYE, FOR DYEING KERATIN MATERIALS | KRT18, ADH1A, ADH5 | NPC1 4068/4885RAB9A 3925/4885FTO 1299/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.