Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | F2 | P00734 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13172184 | 0.92 | RAB9A (0.68) | SRD5A2RAB9AMAPTNPC1DRD2 | |
| SCHEMBL30738988 | 0.80 | SRD5A2 (0.66) | SRD5A2RAB9AMAPTNPC1DRD2 | |
| SCHEMBL2188139 | 0.80 | SRD5A2 (0.66) | SRD5A2RAB9AMAPTNPC1DRD2 | |
| SCHEMBL2186803 | 0.80 | SRD5A2 (0.66) | SRD5A2RAB9AMAPTNPC1DRD2 | |
| SCHEMBL8717537 | 0.79 | LMNA (0.67) | SRD5A2MAPTLMNAF2TSHR | |
| SCHEMBL1115098 | 0.78 | MAPT (0.63) | SRD5A2RAB9AMAPTNPC1SRD5A1 | |
| SCHEMBL30935799 | 0.78 | MAPT (0.63) | SRD5A2RAB9AMAPTNPC1SRD5A1 | |
| SCHEMBL16731946 | 0.77 | TTR (0.58) | RAB9AMAPTNPC1HTR7HTR2B | |
| SCHEMBL545343 | 0.77 | LMNA (0.58) | RAB9AMAPTLMNAF2TSHR | |
| SCHEMBL4918684 | 0.77 | SRD5A2 (0.66) | SRD5A2RAB9AMAPTNPC1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220143201-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | NEKTAR THERAPEUTICS (US) | 2022-05-12 | — | — | US | disclosed |
| US-10695435-B2 | Composition comprising a polymeric reagent | NEKTAR THERAPEUTICS (US) | 2020-06-30 | — | — | US | disclosed |
| US-20190046651-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | NEKTAR THERAPEUTICS | 2019-02-14 | — | — | US | disclosed |
| US-20170348426-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | NEKTAR THERAPEUTICS | 2017-12-07 | — | — | US | disclosed |
| US-9381254-B2 | Methods for preparing polymeric reagents | NEKTAR THERAPEUTICS (US) | 2016-07-05 | — | — | US | disclosed |
| US-20160022830-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | NEKTAR THERAPEUTICS | 2016-01-28 | — | — | US | disclosed |
| US-9090740-B2 | Methods for preparing polymeric reagents | NEKTAR THERAPEUTICS (US) | 2015-07-28 | — | — | US | disclosed |
| US-8911718-B2 | Methods for preparing polymeric reagents | NEKTAR THERAPEUTICS (US) | 2014-12-16 | — | — | US | disclosed |
| US-8703115-B2 | Methods for preparing conjugates | NEKTAR THERAPEUTICS (US) | 2014-04-22 | — | — | US | disclosed |
| US-20140107349-A1 | Methods for Preparing Polymeric Reagents | NEKTAR THERAPEUTICS (US) | 2014-04-17 | — | — | US | disclosed |
| US-20130184443-A1 | Methods for Preparing Conjugates | NEKTAR THERAPEUTICS (US) | 2013-07-18 | — | — | US | disclosed |
| US-8435505-B2 | Pharmaceutical compositions and methods for delivering such compositions | NEKTAR THERAPEUTICS (US) | 2013-05-07 | — | — | US | disclosed |
| US-20120258912-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR DELIVERING SUCH COMPOSITIONS | NEKTAR THERAPEUTICS (US) | 2012-10-11 | — | — | US | disclosed |
| US-8252275-B2 | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates | NEKTAR THERAPEUTICS (US) | 2012-08-28 | — | — | US | disclosed |
| US-8252275-B2 | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates | NEKTAR THERAPEUTICS (US) | 2012-08-28 | — | — | US | disclosed |
| EP-2279758-A2 | Conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates | Nektar Therapeutics (US) | 2011-02-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258912-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR DELIVERING SUCH COMPOSITIONS | ABCG2, SI, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | SRD5A2 1923/4885RAB9A 2000/4885MAPT 339/4885 |
| US-20220143201-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | CD44, FCGRT, C9 | SRD5A2 3458/4885RAB9A 3754/4885MAPT 1479/4885 |
| US-20160022830-A1 | METHODS FOR PREPARING POLYMERIC REAGENTS | PAM, ALKBH3, DNPEP | SRD5A2 4174/4885RAB9A 4002/4885MAPT 3976/4885 |
| US-20130184443-A1 | Methods for Preparing Conjugates | SI, CD44, ABCG2 | SRD5A2 2535/4885RAB9A 1640/4885MAPT 731/4885 |
| US-20190046651-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | CD44, FCGRT, C9 | SRD5A2 3458/4885RAB9A 3754/4885MAPT 1479/4885 |
| US-20170348426-A1 | COMPOSITION COMPRISING A POLYMERIC REAGENT | CD44, FCGRT, C9 | SRD5A2 3458/4885RAB9A 3754/4885MAPT 1479/4885 |
| US-10695435-B2 | Composition comprising a polymeric reagent | CD44, FCGRT, C9 | SRD5A2 3458/4885RAB9A 3754/4885MAPT 1479/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.