Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.60 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.60 |
| ▸ | EDNRA | P25101 | 8/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | F2 | P00734 | 1/20 | 0.53 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.53 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.53 |
| ▸ | GBA1 | P04062 | 2/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | GLB1 | P16278 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9157181 | 0.87 | HDAC4 (0.61) | HDAC4HDAC10HDAC6HDAC5EDNRA | |
| SCHEMBL4126957 | 0.87 | HDAC4 (0.71) | HDAC4HDAC10HDAC6HDAC5EDNRA | |
| SCHEMBL4139459 | 0.87 | HDAC4 (0.75) | HDAC4HDAC10HDAC6HDAC5EDNRA | |
| SCHEMBL10002025 | 0.86 | HDAC4 (0.62) | HDAC4HDAC10HDAC6HDAC5EDNRA | |
| SCHEMBL21103945 | 0.86 | EDNRA (0.60) | HDAC4HDAC10HDAC6HDAC5EDNRA | |
| SCHEMBL4142506 | 0.86 | HDAC4 (0.77) | HDAC4HDAC10HDAC6HDAC5EDNRA | |
| SCHEMBL12041801 | 0.85 | HDAC4 (0.59) | HDAC4HDAC10HDAC6HDAC5EDNRA | |
| Dansyl Ethylenediamine SCHEMBL1293231 | 0.84 | CYP3A4 (0.63) | HDAC4HDAC10HDAC6HDAC5EDNRA | |
| SCHEMBL7161252 | 0.84 | HDAC4 (0.61) | HDAC4HDAC10HDAC6HDAC5EDNRA | |
| SCHEMBL572629 | 0.84 | HDAC4 (0.65) | HDAC4HDAC10HDAC6HDAC5EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | UNIV MONTREAL (CA) | 2023-11-09 | — | — | US | disclosed |
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | UNIV MONTREAL (CA) | 2023-11-09 | — | — | US | disclosed |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | Université de Montréal (CA) | 2023-09-19 | — | — | US | disclosed |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | Université de Montréal (CA) | 2023-09-19 | — | — | US | disclosed |
| US-20210387980-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | Université de Montréal (CA) | 2021-12-16 | — | — | US | disclosed |
| US-20200299461-A1 | SEQUENCE-DEFINED POLYMERS AND METHODS OF MAKING SAME AND USING SAME | CORNELL UNIVERSITY | 2020-09-24 | — | — | US | disclosed |
| US-9682950-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-06-20 | — | — | US | disclosed |
| US-9682950-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide synthase inhibitors | NORTHWESTERN UNIVERSITY (US) | 2017-06-20 | — | — | US | disclosed |
| US-20160152590-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors | NORTHWESTERN UNIVERSITY | 2016-06-02 | — | — | US | disclosed |
| US-9242957-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2016-01-26 | — | — | US | disclosed |
| US-20140256958-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-09-11 | — | — | US | disclosed |
| US-8735606-B2 | Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-05-27 | — | — | US | disclosed |
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NORTHWESTERN UNIVERSITY (US) | 2014-03-06 | — | — | US | disclosed |
| US-20110319293-A1 | SYNTHETIC PROTEASE SUBSTRATES, ASSAY METHODS USING SUCH SUBSTRATES AND KITS FOR PRACTICING THE ASSAY | LIFESENSORS, INC. | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230357221-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | IDH2, TFAM, IDH1 | HDAC4 717/4885HDAC10 789/4885HDAC6 638/4885 |
| US-20110319293-A1 | SYNTHETIC PROTEASE SUBSTRATES, ASSAY METHODS USING SUCH SUBSTRATES AND KITS FOR PRACTICING THE ASSAY | SENP1, STUB1, SENP7 | HDAC4 2925/4885HDAC10 1589/4885HDAC6 1740/4885 |
| US-20160152590-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Synthase Inhibitors | NOS2, NOS1, NOS3 | HDAC4 1995/4885HDAC10 1501/4885HDAC6 1139/4885 |
| US-20210387980-A1 | HETEROCYCLIC MITOCHONDRIAL ACTIVITY INHIBITORS AND USES THEREOF | IDH2, TFAM, NUTF2 | HDAC4 762/4885HDAC10 760/4885HDAC6 624/4885 |
| US-11760754-B2 | Heterocyclic mitochondrial activity inhibitors and uses thereof | IDH2, TFAM, NUTF2 | HDAC4 762/4885HDAC10 760/4885HDAC6 624/4885 |
| US-20140066635-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NOS2, NOS1, NOS3 | HDAC4 1661/4885HDAC10 1277/4885HDAC6 953/4885 |
| US-20140256958-A1 | Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors | NOS2, NOS1, NOS3 | HDAC4 1661/4885HDAC10 1277/4885HDAC6 953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.