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Sugi Predict / Compounds / SCHEMBL1222941

SCHEMBL1222941

SCHEMBL1222941

COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)nc(N)c1Br

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEP1B Q16820 1/20 0.39
▸ KDM4E B2RXH2 6/20 0.37
▸ PKM P14618 3/20 0.37
▸ RCE1 Q9Y256 1/20 0.37
▸ TAS1R3 Q7RTX0 2/20 0.37
▸ TAS1R1 Q7RTX1 2/20 0.37
▸ ALDH1A1 P00352 6/20 0.34
▸ SMN1; SMN2 Q16637 1/20 0.34
▸ L3MBTL1 Q9Y468 1/20 0.34
▸ ACLY P53396 2/20 0.34
▸ HSD17B10 Q99714 1/20 0.34
▸ TAS1R2 Q8TE23 1/20 0.34
▸ DHPS P49366 1/20 0.34
▸ SCN10A Q9Y5Y9 1/20 0.34
▸ ALOX5AP P20292 1/20 0.33
▸ FEN1 P39748 1/20 0.33
▸ TSHR P16473 1/20 0.32
▸ GAA P10253 1/20 0.32
▸ PDGFRB P09619 1/20 0.32
▸ KDR P35968 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1115136 0.91 KDM4E (0.39) MEP1BKDM4EPKMRCE1TAS1R3
SCHEMBL1223170 0.91 KDM4E (0.39) MEP1BKDM4EPKMRCE1TAS1R3
SCHEMBL30151443 0.91 KDM4E (0.39) MEP1BKDM4EPKMRCE1TAS1R3
SCHEMBL1223251 0.91 ALDH1A1 (0.41) MEP1BKDM4ETAS1R3TAS1R1ALDH1A1
SCHEMBL11028213 0.91 KDM4E (0.39) KDM4EPKMRCE1ALDH1A1SMN1; SMN2
SCHEMBL29769728 0.89 KDM4E (0.38) MEP1BKDM4EPKMRCE1TAS1R3
SCHEMBL679753 0.89 KDM4E (0.38) MEP1BKDM4EPKMRCE1TAS1R3
SCHEMBL1918080 0.88 KDM4E (0.37) MEP1BKDM4EPKMRCE1TAS1R3
SCHEMBL1115150 0.88 MEP1B (0.39) MEP1BKDM4EPKMRCE1TAS1R3
SCHEMBL11027447 0.87 KDM4E (0.37) MEP1BKDM4EPKMRCE1TAS1R3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2193120-B1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2016-07-13 — — EP disclosed
US-9199943-B2 2-(poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DOW AGROSCIENCES, LLC. (US) 2015-12-01 — — US disclosed
US-8658791-B2 2-substituted-6-amino-5-alkyl, alkenyl or alkynyl-4-pyrimidinecarboxylic acids and 6-substituted-4-amino-3-alkyl, alkenyl or alkynyl picolinic acids and their use as herbicides DOW AGROSCIENCES, LLC (US) 2014-02-25 — — US disclosed
US-8658791-B2 2-substituted-6-amino-5-alkyl, alkenyl or alkynyl-4-pyrimidinecarboxylic acids and 6-substituted-4-amino-3-alkyl, alkenyl or alkynyl picolinic acids and their use as herbicides DOW AGROSCIENCES, LLC (US) 2014-02-25 — — US disclosed
US-8658791-B2 2-substituted-6-amino-5-alkyl, alkenyl or alkynyl-4-pyrimidinecarboxylic acids and 6-substituted-4-amino-3-alkyl, alkenyl or alkynyl picolinic acids and their use as herbicides DOW AGROSCIENCES, LLC (US) 2014-02-25 — — US disclosed
US-20130237422-A1 2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2013-09-12 — — US disclosed
EP-2634175-A1 Substituted 4-amino-picolinic acids and their use as herbicides Dow AgroSciences LLC (US) 2013-09-04 — — EP disclosed
US-20130210631-A1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3-ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2013-08-15 — — US disclosed
US-20130210631-A1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3-ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2013-08-15 — — US disclosed
US-20130210631-A1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3-ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2013-08-15 — — US disclosed
WO-2009046090-A1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-04-09 — — WO disclosed
WO-2009046090-A1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-04-09 — — WO disclosed
US-20090088322-A1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-04-02 — — US disclosed
US-20090088322-A1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-04-02 — — US disclosed
US-20090088322-A1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2009-04-02 — — US disclosed
EP-1971579-A1 2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 2008-09-24 — — EP disclosed
US-20080091016-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DOW AGROSCIENCES LLC (US) 2008-04-17 — — US disclosed
US-7300907-B2 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DOW AGROSCIENCES LLC (US) 2007-11-27 — — US disclosed
US-20070179059-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides CORTEVA AGRISCIENCE LLC 2007-08-02 — — US disclosed
WO-2007082076-A1 2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2007-07-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130210631-A1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3-ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES AADAC, AASDHPPT, AADAT MEP1B 3281/4885KDM4E 608/4885PKM 2114/4885
US-20130237422-A1 2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES DDT, DDC, HDHD5 MEP1B 3168/4885KDM4E 567/4885PKM 2577/4885
US-20080091016-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DDT, DDC, HDHD5 MEP1B 3168/4885KDM4E 567/4885PKM 2577/4885
US-20090088322-A1 2-SUBSTITUTED-6-AMINO-5-ALKYL, ALKENYL OR ALKYNYL-4-PYRIMIDINECARBOXYLIC ACIDS AND 6-SUBSTITUTED-4-AMINO-3- ALKYL, ALKENYL OR ALKYNYL PICOLINIC ACIDS AND THEIR USE AS HERBICIDES AADAC, AASDHPPT, AADAT MEP1B 3281/4885KDM4E 608/4885PKM 2114/4885
US-20070179059-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DDT, DDC, HDHD5 MEP1B 3168/4885KDM4E 567/4885PKM 2577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.