Sugi Predict

Sugi Predict / Compounds / SCHEMBL679753

SCHEMBL679753

SCHEMBL679753

COC(=O)c1nc(-c2ccc(Cl)c(OC)c2F)nc(N)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.38
▸ PKM P14618 3/20 0.38
▸ RCE1 Q9Y256 1/20 0.38
▸ TAS1R3 Q7RTX0 2/20 0.38
▸ TAS1R1 Q7RTX1 2/20 0.38
▸ MEP1B Q16820 1/20 0.37
▸ DHPS P49366 2/20 0.37
▸ ALDH1A1 P00352 5/20 0.35
▸ SMN1; SMN2 Q16637 1/20 0.35
▸ L3MBTL1 Q9Y468 1/20 0.35
▸ ACLY P53396 2/20 0.35
▸ HSD17B10 Q99714 1/20 0.35
▸ TAS1R2 Q8TE23 1/20 0.34
▸ ALPL P05186 1/20 0.34
▸ SCN10A Q9Y5Y9 1/20 0.34
▸ PTPN1 P18031 1/20 0.33
▸ TSHR P16473 1/20 0.33
▸ GAA P10253 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29769728 1.00 KDM4E (0.38) KDM4EPKMRCE1TAS1R3TAS1R1
SCHEMBL30151443 0.92 KDM4E (0.39) KDM4EPKMRCE1TAS1R3TAS1R1
SCHEMBL1223170 0.92 KDM4E (0.39) KDM4EPKMRCE1TAS1R3TAS1R1
SCHEMBL1115136 0.92 KDM4E (0.39) KDM4EPKMRCE1TAS1R3TAS1R1
SCHEMBL1224460 0.91 KDM4E (0.40) KDM4EPKMRCE1TAS1R3TAS1R1
SCHEMBL1478316 0.90 KDM4E (0.39) KDM4EPKMRCE1DHPSALDH1A1
SCHEMBL1222941 0.89 MEP1B (0.39) KDM4EPKMRCE1TAS1R3TAS1R1
Potassium Ion SCHEMBL679155 0.89 MEP1B (0.34) KDM4EPKMRCE1TAS1R3TAS1R1
SCHEMBL1918080 0.89 KDM4E (0.37) KDM4EPKMRCE1TAS1R3TAS1R1
SCHEMBL716664 0.89 TAS1R3 (0.38) KDM4EPKMRCE1TAS1R3TAS1R1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8785350-B2 Herbicidal compositions for tolerant or resistant soybean crops BAYER INTELLECTUAL PROPERTY GMBH (DE) 2014-07-22 — — US claimed
US-20130023413-A1 HERBICIDAL COMPOSITIONS FOR TOLERANT OR RESISTANT SOYBEAN CROPS BAYER INTELLECTUAL PROPERTY GMBH (DE) 2013-01-24 — — US claimed
US-20110294663-A1 Herbicidal composition for tolerant or resistant corn crops BAYER CROPSCIENCE AG (DE) 2011-12-01 — — US claimed
US-20110287933-A1 Herbicidal composition for tolerant or resistant oilseed rape crops BAYER CROPSCIENCE AG (DE) 2011-11-24 — — US claimed
US-20110287932-A1 HERBICIDAL COMPOSITION FOR TOLERANT OR RESISTANT CEREAL CROPS BAYER CROPSCIENCE AG (DE) 2011-11-24 — — US claimed
US-20110287934-A1 HERBICIDAL COMPOSITION FOR TOLERANT OR RESISTANT RICE CROPS BAYER CROPSCIENCE AG (DE) 2011-11-24 — — US claimed
EP-3458442-B1 SYNTHESIS OF 6-ARYL-4-AMINOPICOLINATES AND 2-ARYL-6-AMINOPYRIMIDINE-4-CARBOXYLATES BY DIRECT SUZUKI COUPLING CORTEVA AGRISCIENCE LLC (US) 2022-12-28 — — EP disclosed
CN-114478507-A Pyrimidine oxazole compound and application thereof 东莞市东阳光农药研发有限公司 2022-05-13 — — CN disclosed
WO-2020133403-A1 SUBSTITUTED PYRIMIDINE ARYL ESTER DERIVATIVE, PREPARATION METHOD THEREFOR, HERBICIDAL COMPOSITION AND APPLICATION THEREOF 青岛清原化合物有限公司 2020-07-02 — — WO disclosed
US-10570114-B2 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling DOW AGROSCIENCES LLC (US) 2020-02-25 — — US disclosed
US-10556865-B2 Synergistic herbicidal composition containing certain pyridine or pyrimidine carboxylic acids and certain cereal and rice herbicides DOW AGROSCIENCES LLC (US) 2020-02-11 — — US disclosed
US-10544121-B2 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling DOW AGROSCIENCES LLC (US) 2020-01-28 — — US disclosed
WO-2019227771-A1 SUBSTITUTED PYRIMIDINE-4-FORMIC ACID DERIVATIVE, HERBICIDAL COMPOSITION AND USE THEREOF 青岛清原化合物有限公司 (CN) 2019-12-05 — — WO disclosed
US-20090062121-A1 SYNERGISTIC HERBICIDAL COMPOSITION CONTAINING CERTAIN PYRIDINE OR PYRIMIDINE CARBOXYLIC ACIDS AND CERTAIN CEREAL AND RICE HERBICIDES DOW AGROSCIENCES LLC (US) 2009-03-05 — — US disclosed
WO-2009029518-A2 SYNERGISTIC HERBICIDAL COMPOSITION CONTAINING CERTAIN PYRIDINE OR PYRIMIDINE CARBOXYLIC ACIDS AND CERTAIN CEREAL AND RICE HERBICIDES DOW AGROSCIENCES LLC (US) 2009-03-05 — — WO disclosed
EP-1971579-A1 2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES Dow AgroSciences LLC (US) 2008-09-24 — — EP disclosed
US-20080091016-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DOW AGROSCIENCES LLC (US) 2008-04-17 — — US disclosed
US-7300907-B2 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DOW AGROSCIENCES LLC (US) 2007-11-27 — — US disclosed
US-20070179059-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides CORTEVA AGRISCIENCE LLC 2007-08-02 — — US disclosed
WO-2007082076-A1 2-(POLY-SUBSTITUTED ARYL)-6-AMINO-5-HALO-4-PYRIMIDINECARBOXYLIC ACIDS AND THEIR USE AS HERBICIDES DOW AGROSCIENCES LLC (US) 2007-07-19 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110287932-A1 HERBICIDAL COMPOSITION FOR TOLERANT OR RESISTANT CEREAL CROPS CYP8B1, HDHD5, HAGH KDM4E 2638/4885PKM 2132/4885RCE1 1871/4885
US-10570114-B2 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling DDC, AAAS, AASDHPPT KDM4E 12/4885PKM 1750/4885RCE1 751/4885
US-20110294663-A1 Herbicidal composition for tolerant or resistant corn crops CRY1, CYP8B1, CNPY2 KDM4E 2437/4885PKM 2006/4885RCE1 1815/4885
US-20080091016-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DDT, DDC, HDHD5 KDM4E 567/4885PKM 2577/4885RCE1 2426/4885
US-10556865-B2 Synergistic herbicidal composition containing certain pyridine or pyrimidine carboxylic acids and certain cereal and rice herbicides DHFR, DPYD, DDT KDM4E 1949/4885PKM 1157/4885RCE1 1896/4885
US-20110287933-A1 Herbicidal composition for tolerant or resistant oilseed rape crops CYP8B1, HDHD5, NCEH1 KDM4E 2292/4885PKM 3710/4885RCE1 1453/4885
US-20090062121-A1 SYNERGISTIC HERBICIDAL COMPOSITION CONTAINING CERTAIN PYRIDINE OR PYRIMIDINE CARBOXYLIC ACIDS AND CERTAIN CEREAL AND RICE HERBICIDES DHFR, DPYD, DDT KDM4E 1949/4885PKM 1157/4885RCE1 1896/4885
US-20110287934-A1 HERBICIDAL COMPOSITION FOR TOLERANT OR RESISTANT RICE CROPS CYP8B1, DDT, HDHD5 KDM4E 2418/4885PKM 2288/4885RCE1 2583/4885
US-20130023413-A1 HERBICIDAL COMPOSITIONS FOR TOLERANT OR RESISTANT SOYBEAN CROPS CTH, GGH, CBR3 KDM4E 2699/4885PKM 2710/4885RCE1 1510/4885
US-20070179059-A1 2-(Poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides DDT, DDC, HDHD5 KDM4E 567/4885PKM 2577/4885RCE1 2426/4885
US-10544121-B2 Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling DDC, AAAS, AASDHPPT KDM4E 12/4885PKM 1750/4885RCE1 751/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.