Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | ACHE | P22303 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphonic Acid SCHEMBL9017640 | 0.88 | ALDH1A1 (0.40) | ALDH1A1ACHECYP3A4AHRPTPN1 | |
| SCHEMBL811578 | 0.84 | ALDH1A1 (0.59) | ALDH1A1CYP3A4AHRMAPTHPGD | |
| SCHEMBL21263 | 0.84 | ALDH1A1 (0.69) | ALDH1A1CYP3A4AHRCYP1A1CYP1B1 | |
| SCHEMBL28298270 | 0.81 | ALDH1A1 (0.65) | ALDH1A1CYP3A4AHRCYP1A1CYP1B1 | |
| SCHEMBL1816933 | 0.81 | ALDH1A1 (0.65) | ALDH1A1CYP3A4AHRCYP1A1CYP1B1 | |
| SCHEMBL12501 | 0.81 | ALDH1A1 (0.73) | ALDH1A1ACHECYP3A4AHRPTPN1 | |
| SCHEMBL145855 | 0.81 | ALDH1A1 (0.62) | ALDH1A1ACHECYP3A4PTPN1KDM4E | |
| SCHEMBL29587173 | 0.78 | ALDH1A1 (0.59) | ALDH1A1ACHECYP3A4PTPN1KDM4E | |
| SCHEMBL13667485 | 0.76 | GRM5 (0.54) | TDP1 | |
| SCHEMBL3541751 | 0.76 | RAPGEF4 (0.32) | ALDH1A1CYP3A4MAPTTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 129 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113511960-A | Synthesis method of 1-chloro-3-methoxy-5-methylbenzene | 郑州华赞医药科技有限公司 | 2021-10-19 | — | — | CN | claimed |
| US-12398136-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-08-26 | — | — | US | disclosed |
| US-12331048-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-06-17 | — | — | US | disclosed |
| US-12312351-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | VENTUS THERAPEUTICS U.S., INC. (US) | 2025-05-27 | — | — | US | disclosed |
| EP-4499638-A1 | PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES | Ventus Therapeutics U.S., Inc. (US) | 2025-02-05 | — | — | EP | disclosed |
| US-20240409540-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | VENTUS THERAPEUTICS U S INC (US) | 2024-12-12 | — | — | US | disclosed |
| US-20240383896-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | VENTUS THERAPEUTICS U.S., INC. | 2024-11-21 | — | — | US | disclosed |
| US-20240360130-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | VENTUS THERAPEUTICS U.S., INC. | 2024-10-31 | — | — | US | disclosed |
| US-20240174661-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | VENTUS THERAPEUTICS U.S., INC. | 2024-05-30 | — | — | US | disclosed |
| US-11858907-B2 | Kinase modulators | RHIZEN PHARMACEUTICALS AG (CH) | 2024-01-02 | — | — | US | disclosed |
| WO-2009010530-A1 | BICYCLIC HETEROARYL COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-01-22 | — | — | WO | disclosed |
| WO-2008117061-A2 | TETRAHYDROISOQUINOLINES AS TUMOUR GROWTH INHIBITORS | STERIX LIMITED (GB) | 2008-10-02 | — | — | WO | disclosed |
| US-20080200433-A1 | Molecular Chaperone Function Regulator | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-08-21 | — | — | US | disclosed |
| US-20080200433-A1 | Molecular Chaperone Function Regulator | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2008-08-21 | — | — | US | disclosed |
| WO-2008076046-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| US-20070265260-A1 | Quinazoline derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-11-15 | — | — | US | disclosed |
| US-20070265260-A1 | Quinazoline derivatives | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-11-15 | — | — | US | disclosed |
| US-7294629-B2 | Quinazoline derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2007-11-13 | — | — | US | disclosed |
| US-7294629-B2 | Quinazoline derivatives | MITSUBISHI PHARMA CORPORATION (JP) | 2007-11-13 | — | — | US | disclosed |
| WO-2004085408-A1 | 2, 3, 6-TRISUBSTITUTED-4-PYRIMIDONE DERIVATIVES | MITSUBISHI PHARMA CORPORATION (JP) | 2004-10-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240383896-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | NLRP3, NLRP1, NOD1 | ALDH1A1 3611/4885ACHE 4698/4885CYP3A4 809/4885 |
| US-12331048-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | NLRP3, NLRP1, NOD1 | ALDH1A1 3611/4885ACHE 4698/4885CYP3A4 809/4885 |
| US-20240360130-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | NLRP3, NLRP1, NOD1 | ALDH1A1 3588/4885ACHE 4720/4885CYP3A4 755/4885 |
| US-12398136-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | NLRP3, NLRP1, NOD1 | ALDH1A1 3611/4885ACHE 4698/4885CYP3A4 809/4885 |
| US-20240174661-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | NLRP3, NLRP1, NOD1 | ALDH1A1 3611/4885ACHE 4698/4885CYP3A4 809/4885 |
| US-11858907-B2 | Kinase modulators | RPS6KA1, RPS6KA2, PRKAR2A | ALDH1A1 3748/4885ACHE 3993/4885CYP3A4 3840/4885 |
| US-20240409540-A1 | PYRIDO-[3,4-d]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 INHIBITORS | NLRP3, NLRP1, NOD1 | ALDH1A1 3611/4885ACHE 4698/4885CYP3A4 809/4885 |
| US-20070265260-A1 | Quinazoline derivatives | TYK2, ROR1, JAK1 | ALDH1A1 3381/4885ACHE 4648/4885CYP3A4 2509/4885 |
| US-12312351-B2 | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors | NLRP3, NLRP1, NOD1 | ALDH1A1 3611/4885ACHE 4698/4885CYP3A4 809/4885 |
| US-20080200433-A1 | Molecular Chaperone Function Regulator | HSPBP1, HSF1, HSPH1 | ALDH1A1 2634/4885ACHE 4665/4885CYP3A4 3953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.