SCHEMBL1226091

SCHEMBL1226091

O=C(O)CC(O)CC(O)C(=O)O

nearest known ligand 0.62

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.62
SLC22A6 Q4U2R8 1/20 0.60
GABRR1 P24046 2/20 0.50
LMNA P02545 1/20 0.50
MAPT P10636 1/20 0.44
TET2 Q6N021 6/20 0.44
KDM4A O75164 2/20 0.44
KDM4C Q9H3R0 2/20 0.44
KDM2A Q9Y2K7 2/20 0.44
TET3 O43151 2/20 0.44
OR51E2 Q9H255 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
TET1 Q8NFU7 1/20 0.41
GPR84 Q9NQS5 4/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9005323 1.00 SMN1; SMN2 (0.62) SMN1; SMN2SLC22A6GABRR1LMNAMAPT
SCHEMBL6453593 0.83 SLC22A6 (0.75) SMN1; SMN2SLC22A6GABRR1LMNAMAPT
SCHEMBL20134681 0.81 SLC22A6 (0.63) SMN1; SMN2SLC22A6GABRR1LMNAMAPT
SCHEMBL25427974 0.78 SLC22A6 (0.67) SMN1; SMN2SLC22A6GABRR1LMNAMAPT
SCHEMBL27928314 0.78 TET2 (0.48) SMN1; SMN2SLC22A6TET2KDM4AKDM4C
Malic Acid SCHEMBL14125844 0.77 SMN1; SMN2 (1.00) SMN1; SMN2SLC22A6GABRR1LMNATET2
Malic Acid SCHEMBL856 0.77
Malic Acid SCHEMBL256122 0.77
Malic Acid SCHEMBL98496 0.77
Malic Acid SCHEMBL89131 0.77 SMN1; SMN2 (1.00) SMN1; SMN2SLC22A6GABRR1LMNATET2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109659604-B Solid electrolyte composite material and preparation method and application thereof 北京大学深圳研究生院 2020-09-01 CN claimed
CN-109659604-A A kind of solid electrolyte composite material and preparation method and application 北京大学深圳研究生院 2019-04-19 CN claimed
CN-105745327-A High-yield route for producing compounds from renewable resources 兹莫克姆有限公司 2016-07-06 CN claimed
EP-1439162-B1 PROCESS FOR PRODUCING OPTICALLY ACTIVE 3,5-DIHYDROXYCARBOXYLIC ACID DERIVATIVE KANEKA CORP (JP) 2008-03-26 EP claimed
US-6998495-B2 Method for producing optically active 3,5-dihydroxycarboxylic acid derivative KANEKA CORPORATION (JP) 2006-02-14 US claimed
US-20040254392-A1 Process for producing optically active 3,5-dihydroxycarboxylic acid derivative KANEKA CORPORATION (JP) 2004-12-16 US claimed
EP-1439162-A1 PROCESS FOR PRODUCING OPTICALLY ACTIVE 3,5-DIHYDROXYCARBOXYLIC ACID DERIVATIVE KANEKA CORPORATION (JP) 2004-07-21 EP claimed
EP-0464817-B1 2,4-Dihydroxyadipic acid derivative KANEGAFUCHI CHEMICAL IND (JP) 1996-10-09 EP claimed
US-5214197-A 2,4-DIHYDROXYADIPIC ACID DERIVATIVE KANEGAFUCHI CHEMICAL INDUSTRY CO., LTD. (JP) 1993-05-25 US claimed
EP-0464817-A1 2,4-Dihydroxyadipic acid derivative Kanegafuchi Chemical Industry Co., Ltd. (JP) 1992-01-08 EP claimed
JP-4069355-A None JP disclosed
US-12104160-B2 Production of 4,6-dihydroxy-2-oxo-hexanoic acid ZYMOCHEM, INC. (US) 2024-10-01 US disclosed
US-20230295195-A1 ANTIMICROBIAL ORGANOSILANES Tipikos Pharmaceuticals, Inc. (US) 2023-09-21 US disclosed
US-20230143708-A1 ANTIMICROBIAL ORGANOSILANES TOPIKOS PHARMACEUTICALS, INC. (US) 2023-05-11 US disclosed
US-20220389433-A1 HIGH YIELD ROUTE FOR THE PRODUCTION OF COMPOUNDS FROM RENEWABLE SOURCES ZYMOCHEM, INC. 2022-12-08 US disclosed
US-5214197-A 2,4-DIHYDROXYADIPIC ACID DERIVATIVE KANEGAFUCHI CHEMICAL INDUSTRY CO., LTD. (JP) 1993-05-25 US disclosed
JP-H0469355-A 2,4-DIHYDROXYADIPIC ACID DERIVATIVE KANEGAFUCHI CHEM IND CO LTD 1992-03-04 JP disclosed
EP-0464817-A1 2,4-Dihydroxyadipic acid derivative Kanegafuchi Chemical Industry Co., Ltd. (JP) 1992-01-08 EP disclosed
EP-0464817-A1 2,4-Dihydroxyadipic acid derivative Kanegafuchi Chemical Industry Co., Ltd. (JP) 1992-01-08 EP disclosed
EP-0464817-A1 2,4-Dihydroxyadipic acid derivative Kanegafuchi Chemical Industry Co., Ltd. (JP) 1992-01-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040254392-A1 Process for producing optically active 3,5-dihydroxycarboxylic acid derivative HAO2, GRHPR, HDHD5 SMN1; SMN2 4843/4885SLC22A6 4289/4885GABRR1 196/4885
US-20230143708-A1 ANTIMICROBIAL ORGANOSILANES ARG1, ACMSD, AAAS SMN1; SMN2 3283/4885SLC22A6 1842/4885GABRR1 3637/4885
US-20230295195-A1 ANTIMICROBIAL ORGANOSILANES ARG1, ACMSD, AAAS SMN1; SMN2 3283/4885SLC22A6 1842/4885GABRR1 3637/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.