Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 3/20 | 0.54 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.54 |
| ▸ | ORAI2 | Q96SN7 | 2/20 | 0.54 |
| ▸ | ORAI3 | Q9BRQ5 | 2/20 | 0.54 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | LPL | P06858 | 3/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 3/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.41 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12266165 | 0.87 | ORAI1 (0.55) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL692342 | 0.82 | ENPP2 (0.67) | TP53LPLLIPGENPP2ALDH1A1 | |
| SCHEMBL12270775 | 0.82 | LPL (0.61) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL14135196 | 0.81 | LPL (0.41) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL12318713 | 0.80 | ORAI1 (0.48) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL3282237 | 0.79 | TRPV6 (0.52) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL2406124 | 0.79 | TRPV6 (0.78) | TRPV6ORAI1ORAI2ORAI3PCSK9 | |
| SCHEMBL12266207 | 0.79 | SIGMAR1 (0.43) | TP53LPLLIPGENPP2CYP1A2 | |
| SCHEMBL14135249 | 0.79 | S1PR1 (0.40) | TRPV6ORAI1ORAI2ORAI3LPL | |
| SCHEMBL12266170 | 0.79 | S1PR1 (0.40) | TRPV6ORAI1ORAI2ORAI3LPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853424-B2 | Protein cross-linking inhibitor | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2014-10-07 | — | — | US | disclosed |
| US-8017809-B2 | Bisboron compound | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-09-13 | — | — | US | disclosed |
| US-20110212919-A1 | PROTEIN CROSS-LINKING INHIBITOR | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-09-01 | — | — | US | disclosed |
| US-20100087645-A1 | NOVEL BISBORON COMPOUND | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2010-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212919-A1 | PROTEIN CROSS-LINKING INHIBITOR | BAZ2B, PRMT1, BRIX1 | TRPV6 4868/4885ORAI1 4605/4885ORAI2 3906/4885 |
| US-20100087645-A1 | NOVEL BISBORON COMPOUND | KCNMB4, CA2, NR0B2 | TRPV6 61/4885ORAI1 58/4885ORAI2 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.