Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16419854 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1POLBTSHRTHRB | |
| SCHEMBL22930458 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1POLBTSHRTHRB | |
| SCHEMBL20235111 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1POLBTSHRTHRB | |
| SCHEMBL5611814 | 0.95 | KDM4E (0.41) | KDM4EALDH1A1POLBTSHRTHRB | |
| SCHEMBL22692193 | 0.91 | KDM4E (0.40) | KDM4EALDH1A1POLBTSHRTHRB | |
| SCHEMBL9541679 | 0.90 | KDM4E (0.45) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL14198320 | 0.90 | KDM4E (0.45) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL9540608 | 0.90 | KDM4E (0.45) | KDM4EALDH1A1POLBMEN1KMT2A | |
| SCHEMBL9972442 | 0.88 | KDM4E (0.43) | KDM4EALDH1A1POLBTSHRTHRB | |
| SCHEMBL10330545 | 0.88 | KDM4E (0.43) | KDM4EALDH1A1POLBTSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118139956-A | Boron-free water-based lubricant for plastic working | 汉高股份有限及两合公司 | 2024-06-04 | — | — | CN | claimed |
| CN-118139956-A | Boron-free water-based lubricant for plastic working | 汉高股份有限及两合公司 | 2024-06-04 | — | — | CN | disclosed |
| US-11161841-B2 | Modulators of proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2021-11-02 | — | — | US | disclosed |
| US-11065231-B2 | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2021-07-20 | — | — | US | disclosed |
| WO-2021104120-A1 | POLYETHYLENE GLYCOL CONJUGATE MEDICAMENT, PREPARATION METHOD THERFOR AND USE THEREOF | 重庆阿普格雷生物科技有限公司 | 2021-06-03 | — | — | WO | disclosed |
| US-20190315732-A1 | MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2019-10-17 | — | — | US | disclosed |
| US-20190151295-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES | ARVINAS OPERATIONS, INC. | 2019-05-23 | — | — | US | disclosed |
| WO-2018119448-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |
| US-9561287-B2 | Carrier-linked treprostinil prodrugs | ASCENDIS PHARMA A/S (DK) | 2017-02-07 | — | — | US | disclosed |
| US-9533056-B2 | Dipeptide-based prodrug linkers for aliphatic amine-containing drugs | ASCENDIS PHARMA AS (DK) | 2017-01-03 | — | — | US | disclosed |
| US-20150196667-A1 | STERILIZATION OF BIODEGRADABLE HYDROGELS | ASCENDIS PHARMA AS (DK) | 2015-07-16 | — | — | US | disclosed |
| US-8986609-B2 | Sterilization of biodegradable hydrogels | ASCENDIS PHARMA A/S (DK) | 2015-03-24 | — | — | US | disclosed |
| US-20140296150-A1 | Carrier-Linked Treprostinil Prodrugs | ASCENDIS PHARMA A/S (DK) | 2014-10-02 | — | — | US | disclosed |
| US-8486183-B2 | Alkylamino alkyloxy (alcohol) monoalkyl ether for acid gas scrubbing process | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2013-07-16 | — | — | US | disclosed |
| US-20130030359-A1 | DIPEPTIDE-BASED PRODRUG LINKERS FOR AROMATIC AMINE-CONTAINING DRUGS | ASCENDIS PHARMA A/S (DK) | 2013-01-31 | — | — | US | disclosed |
| US-20120253071-A1 | Sterilization of biodegradable hydrogels | ASCENDIS PHARMA A/S (DK) | 2012-10-04 | — | — | US | disclosed |
| US-20120184489-A1 | PRODRUGS COMPRISING AN INSULIN LINKER CONJUGATE | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2012-07-19 | — | — | US | disclosed |
| US-20110202328-A1 | System for the determination of selective absorbent molecules through predictive correlations | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110202328-A1 | System for the determination of selective absorbent molecules through predictive correlations | EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2011-08-18 | — | — | US | disclosed |
| US-20100037775-A1 | ALKYLAMINO ALKYLOXY (ALCOHOL) MONOALKYL ETHER FOR ACID GAS SCRUBBING PROCESS | EXXON-MOBIL RESEARCH AND ENGINEERING COMPANY (US) | 2010-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140296150-A1 | Carrier-Linked Treprostinil Prodrugs | PAH, TK1, SLC16A1 | KDM4E 3700/4885ALDH1A1 1137/4885POLB 1603/4885 |
| US-20190151295-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 POLYPEPTIDES | IRAK1, IRAK4, IRAK2 | KDM4E 1071/4885ALDH1A1 2896/4885POLB 4307/4885 |
| US-20100037775-A1 | ALKYLAMINO ALKYLOXY (ALCOHOL) MONOALKYL ETHER FOR ACID GAS SCRUBBING PROCESS | ALKBH3, ALKBH1, ALKBH2 | KDM4E 721/4885ALDH1A1 276/4885POLB 1180/4885 |
| US-20130030359-A1 | DIPEPTIDE-BASED PRODRUG LINKERS FOR AROMATIC AMINE-CONTAINING DRUGS | DNPEP, DDC, PEPD | KDM4E 666/4885ALDH1A1 847/4885POLB 3068/4885 |
| US-11065231-B2 | Compounds and methods for the targeted degradation of interleukin-1 receptor- associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | KDM4E 1071/4885ALDH1A1 2896/4885POLB 4307/4885 |
| US-20120184489-A1 | PRODRUGS COMPRISING AN INSULIN LINKER CONJUGATE | IAPP, IGF1R, INSR | KDM4E 2506/4885ALDH1A1 468/4885POLB 3871/4885 |
| US-20150196667-A1 | STERILIZATION OF BIODEGRADABLE HYDROGELS | USP3, USP30, USP4 | KDM4E 596/4885ALDH1A1 664/4885POLB 2658/4885 |
| US-20190315732-A1 | MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | MDM2, CRBN, VHL | KDM4E 2053/4885ALDH1A1 2958/4885POLB 2694/4885 |
| US-20120253071-A1 | Sterilization of biodegradable hydrogels | USP3, USP30, USP4 | KDM4E 596/4885ALDH1A1 664/4885POLB 2658/4885 |
| US-11161841-B2 | Modulators of proteolysis and associated methods of use | MDM2, CRBN, VHL | KDM4E 2053/4885ALDH1A1 2958/4885POLB 2694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.