Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | ALPG | P10696 | 2/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.38 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24430222 | 0.84 | FDPS (0.58) | FDPSKMT2AALDH1A1POLBTSHR | |
| SCHEMBL20254251 | 0.84 | FDPS (0.50) | FDPSKMT2AALDH1A1POLBTSHR | |
| SCHEMBL18010007 | 0.83 | FDPS (0.53) | FDPSKMT2AALDH1A1POLBTSHR | |
| SCHEMBL4235515 | 0.83 | FDPS (0.62) | FDPSKMT2AALDH1A1POLBTSHR | |
| SCHEMBL3836216 | 0.82 | KMT2A (0.52) | FDPSKMT2AALDH1A1POLBTSHR | |
| SCHEMBL6521463 | 0.81 | FDPS (0.54) | FDPSKMT2AALDH1A1POLBTSHR | |
| SCHEMBL11212719 | 0.79 | ALDH1A1 (0.58) | FDPSKMT2AALDH1A1POLBTSHR | |
| SCHEMBL26523553 | 0.78 | FDPS (0.51) | FDPSKMT2AALDH1A1POLBTSHR | |
| SCHEMBL13739966 | 0.77 | TLR8 (0.52) | FDPSKMT2AALDH1A1POLBTSHR | |
| SCHEMBL4772963 | 0.77 | KMT2A (0.59) | FDPSKMT2AALDH1A1POLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220106302-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2022-04-07 | — | — | US | disclosed |
| US-11028078-B2 | Itraconazole analogs and use thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2021-06-08 | — | — | US | disclosed |
| US-20210087147-A1 | SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME | NodThera Limited (GB) | 2021-03-25 | — | — | US | disclosed |
| EP-3689931-A1 | CATALYST FOR DISSOCIATION OF BLOCKING AGENT FOR BLOCKED ISOCYANATES, AND THERMOSETTING COMPOSITION CONTAINING SAID CATALYST FOR DISSOCIATION OF BLOCKING AGENT | Koei Chemical Company, Limited (JP) | 2020-08-05 | — | — | EP | disclosed |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2019-02-07 | — | — | US | disclosed |
| US-20180021723-A1 | GAS TREATING SOLUTIONS CONTAINING IMIDAZOLE-AMINE COMPOUNDS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA | 2018-01-25 | — | — | US | disclosed |
| US-9096527-B2 | TRPM8 antagonists and their use in treatments | AMGEN INC. (US) | 2015-08-04 | — | — | US | disclosed |
| US-8952009-B2 | Chroman derivatives as TRPM8 inhibitors | AMGEN INC. (US) | 2015-02-10 | — | — | US | disclosed |
| US-20150031668-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | AMGEN INC (US) | 2015-01-29 | — | — | US | disclosed |
| WO-2014100454-A1 | ENZYMATIC CHEMICAL PROCESSING IN A FIBER CONDUIT APPARATUS | MASSINGILL JOHN LEE (US) | 2014-06-26 | — | — | WO | disclosed |
| US-20140171406-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2014-06-19 | — | — | US | disclosed |
| US-20140171639-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2014-06-19 | — | — | US | disclosed |
| WO-2014047195-A1 | USE OF A FIBER CONDUIT CONTACTOR FOR METAL AND/OR METALLOID EXTRACTION | CHEMTOR, LP (US) | 2014-03-27 | — | — | WO | disclosed |
| US-20140045855-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | AMGEN INC. (US) | 2014-02-13 | — | — | US | disclosed |
| US-20130157996-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | AMGEN INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031668-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | TRPM8, TRPM5, TRPM7 | FDPS 2950/4885KMT2A 2639/4885ALDH1A1 4469/4885 |
| US-20190040046-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | SHH, GLI1, KDR | FDPS 2802/4885KMT2A 3182/4885ALDH1A1 1448/4885 |
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | CCNY, CCNA1, CCNA2 | FDPS 769/4885KMT2A 1997/4885ALDH1A1 1168/4885 |
| US-20140045855-A1 | CHROMAN DERIVATIVES AS TRPM8 INHIBITORS | TRPM8, TRPM5, TRPM7 | FDPS 2950/4885KMT2A 2639/4885ALDH1A1 4469/4885 |
| US-20220106302-A1 | ITRACONAZOLE ANALOGS AND USE THEREOF | CYP3A4, SHH, GLI1 | FDPS 1333/4885KMT2A 3683/4885ALDH1A1 428/4885 |
| US-11028078-B2 | Itraconazole analogs and use thereof | SHH, GLI1, KDR | FDPS 2802/4885KMT2A 3182/4885ALDH1A1 1448/4885 |
| US-20140171639-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | TRPM8, TRPM7, TRPM5 | FDPS 2132/4885KMT2A 2606/4885ALDH1A1 4051/4885 |
| US-20140171406-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | TRPM8, TRPM7, TRPM5 | FDPS 2132/4885KMT2A 2606/4885ALDH1A1 4051/4885 |
| US-20130157996-A1 | TRPM8 ANTAGONISTS AND THEIR USE IN TREATMENTS | TRPM8, TRPM7, TRPM5 | FDPS 2132/4885KMT2A 2606/4885ALDH1A1 4051/4885 |
| US-20180021723-A1 | GAS TREATING SOLUTIONS CONTAINING IMIDAZOLE-AMINE COMPOUNDS | NISCH, INMT, GMPS | FDPS 2696/4885KMT2A 770/4885ALDH1A1 2670/4885 |
| US-20210087147-A1 | SELECTIVE INHIBITORS OF NLRP3 INFLAMMASOME | NLRP3, NOD1, NLRP1 | FDPS 539/4885KMT2A 4593/4885ALDH1A1 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.