Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 11/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12560651 | 0.80 | LMNA (0.44) | CCR2PTGS2L3MBTL1LMNAHSD17B10 | |
| SCHEMBL4206943 | 0.79 | TRPV4 (0.35) | — | |
| SCHEMBL25728029 | 0.79 | ALDH1A1 (0.36) | LMNA | |
| SCHEMBL6732039 | 0.78 | L3MBTL1 (0.36) | CCR2PTGS2L3MBTL1 | |
| SCHEMBL16825498 | 0.76 | EPAS1 (0.43) | CCR2LMNA | |
| SCHEMBL28354575 | 0.75 | CCR2 (0.39) | CCR2PTGS2L3MBTL1LMNAHSD17B10 | |
| SCHEMBL8176124 | 0.73 | CCR2 (0.38) | CCR2PTGS2L3MBTL1LMNA | |
| SCHEMBL31001623 | 0.73 | CCR2 (0.38) | CCR2PTGS2L3MBTL1LMNA | |
| SCHEMBL16825580 | 0.73 | CCR2 (0.33) | CCR2L3MBTL1 | |
| SCHEMBL16825551 | 0.72 | VCAM1 (0.40) | CCR2LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012103113-A1 | PYRAZINE AND IMIDAZOLIDINE DERIVATIVES AND THEIR USES TO TREAT HEPATITIS C | GILEAD PHARMASSET, LLC (US) | 2012-08-02 | — | — | WO | disclosed |