Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | HNF4A | P41235 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1919908 | 0.80 | HSD17B10 (0.39) | HSD17B10GPR35HNF4AALDH1A1HPGD | |
| SCHEMBL26106532 | 0.77 | KDM4E (0.41) | ALDH1A1KDM4E | |
| SCHEMBL17939880 | 0.74 | HSD17B10 (0.39) | HSD17B10GPR35ALDH1A1HPGDKDM4E | |
| SCHEMBL27204905 | 0.74 | TDP1 (0.39) | HSD17B10HNF4AALDH1A1HPGDKDM4E | |
| SCHEMBL24745852 | 0.73 | ALDH1A1 (0.44) | HSD17B10GPR35ALDH1A1HPGDKDM4E | |
| SCHEMBL7352417 | 0.72 | MAPT (0.45) | HSD17B10KEAP1NFE2L2ALDH1A1HPGD | |
| SCHEMBL13125462 | 0.72 | LMNA (0.38) | HSD17B10ALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL17339030 | 0.71 | TDP1 (0.39) | HSD17B10HNF4AALDH1A1HPGDKDM4E | |
| SCHEMBL17939966 | 0.71 | ROCK1 (0.39) | KDM4ETDP1 | |
| SCHEMBL24515305 | 0.70 | KDM4E (0.41) | HSD17B10GPR35ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170340610-A1 | RORgammaT INHIBITORS | MERCK SHARP & DOHME LLC | 2017-11-30 | — | — | US | disclosed |
| US-9603838-B2 | RORgammaT inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-28 | — | — | US | disclosed |
| US-20150297566-A1 | RORgammaT INHIBITORS | MERCK SHARP & DOHME LLC | 2015-10-22 | — | — | US | disclosed |
| US-9095583-B2 | RORgammaT inhibitors | MERCK SHARP & DOHME CORP. (US) | 2015-08-04 | — | — | US | disclosed |
| US-20140038942-A1 | RORgammaT INHIBITORS | MERCK SHARP & DOHME B.V. (NL) | 2014-02-06 | — | — | US | disclosed |
| EP-2683693-A1 | RORGAMMAT INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-01-15 | — | — | EP | disclosed |
| WO-2012106995-A1 | RORGAMMAT INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2012-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150297566-A1 | RORgammaT INHIBITORS | RORB, RORC, RORA | HSD17B10 1186/4885GPR35 88/4885KEAP1 2775/4885 |
| US-20170340610-A1 | RORgammaT INHIBITORS | RORB, RORC, RORA | HSD17B10 1208/4885GPR35 89/4885KEAP1 2633/4885 |
| US-20140038942-A1 | RORgammaT INHIBITORS | RORB, RORC, RORA | HSD17B10 1208/4885GPR35 89/4885KEAP1 2633/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.