Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | THRA | P10827 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5693323 | 0.74 | CA2 (0.41) | LOXL2SMN1; SMN2ADRB2HPGDNPC1 | |
| SCHEMBL28835088 | 0.73 | LOXL2 (0.62) | LOXL2CHEK2ADRB2PTGDR2FFAR1 | |
| Hydrochloric Acid SCHEMBL20899882 | 0.73 | CA2 (0.40) | LOXL2ADRB2HPGDNPC1RAB9A | |
| SCHEMBL4611702 | 0.70 | PSIP1 (0.41) | LMNAMAPK1ALDH1A1POLBKDM4E | |
| SCHEMBL3121483 | 0.68 | GABRP (0.41) | LMNAMAPK1ALDH1A1POLBKDM4E | |
| SCHEMBL28816427 | 0.67 | LOXL2 (0.45) | LOXL2CHEK2ADRB2PTGDR2KAT6A | |
| SCHEMBL28051301 | 0.67 | LOXL2 (0.53) | LOXL2MAPK1ALDH1A1CHEK2THRA | |
| SCHEMBL16880298 | 0.66 | PSIP1 (0.47) | LMNAMAPK1ALDH1A1POLBKDM4E | |
| SCHEMBL5989736 | 0.66 | THRA (0.46) | LOXL2SMN1; SMN2ALDH1A1THRATHRB | |
| SCHEMBL30130504 | 0.65 | ALDH1A1 (0.39) | LOXL2LMNASMN1; SMN2ALDH1A1CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012100734-A1 | COMPOUNDS USEFUL AS RETINOID-RELATED ORPHAN RECEPTOR GAMMA MODULATORS | GLAXO GROUP LIMITED (GB) | 2012-08-02 | — | — | WO | disclosed |