Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 4/20 | 0.59 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.59 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13574158 | 0.93 | HPGD (0.53) | TNKSTNKS2HPGDPOLBALDH1A1 | |
| SCHEMBL15462269 | 0.87 | TNKS (0.61) | TNKSTNKS2HPGDPOLBALDH1A1 | |
| SCHEMBL3869028 | 0.77 | TNKS (0.67) | TNKSTNKS2HPGDPOLBLMNA | |
| SCHEMBL16010683 | 0.74 | KDM4E (0.52) | TNKSTNKS2HPGDPOLBALDH1A1 | |
| SCHEMBL12549629 | 0.74 | TNKS (1.00) | TNKSTNKS2HPGDPOLBALDH1A1 | |
| SCHEMBL10475504 | 0.70 | TSHR (0.60) | TNKSTNKS2HPGDALDH1A1TSHR | |
| SCHEMBL6520182 | 0.69 | POLB (0.69) | TNKSTNKS2HPGDPOLBLMNA | |
| SCHEMBL12791230 | 0.68 | LMNA (0.72) | TNKSTNKS2HPGDPOLBLMNA | |
| SCHEMBL6520217 | 0.68 | KMT2A (0.71) | TNKSTNKS2HPGDPOLBLMNA | |
| SCHEMBL11960890 | 0.67 | MAPK10 (0.63) | TNKSTNKS2HPGDPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-31 | — | — | US | disclosed |
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-12-31 | — | — | US | disclosed |
| US-9045416-B2 | WNT protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-06-02 | — | — | US | disclosed |
| US-9045416-B2 | WNT protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2015-06-02 | — | — | US | disclosed |
| US-20140255426-A1 | WNT PATHWAY INHIBITORS FOR TREATING VIRAL INFECTIONS | EMORY UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | UNIV TEXAS (US) | 2014-02-06 | — | — | US | disclosed |
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | UNIV TEXAS (US) | 2014-02-06 | — | — | US | disclosed |
| US-8445491-B2 | Wnt protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-21 | — | — | US | disclosed |
| US-8445491-B2 | Wnt protein signalling inhibitors | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2013-05-21 | — | — | US | disclosed |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2011-06-09 | — | — | US | disclosed |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM | 2011-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140038922-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | TNKS 2561/4885TNKS2 1132/4885HPGD 2617/4885 |
| US-20110136813-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | TNKS 2561/4885TNKS2 1132/4885HPGD 2617/4885 |
| US-20150374696-A1 | WNT PROTEIN SIGNALLING INHIBITORS | WNT1, WNT3A, DKK1 | TNKS 2561/4885TNKS2 1132/4885HPGD 2617/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.