Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | TDO2 | P48775 | 1/20 | 0.51 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28146640 | 0.83 | TRPA1 (0.48) | IDO1TDO2TRPA1LMNACHRM1 | |
| SCHEMBL14121796 | 0.82 | ALDH1A1 (0.51) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL19433124 | 0.81 | CA12 (0.47) | ALOX15ALOX12CA1CA2CA9 | |
| SCHEMBL12313570 | 0.80 | ACHE (0.50) | IDO1TDO2LMNAACHEFFAR1 | |
| SCHEMBL4962026 | 0.79 | ALDH1A1 (0.48) | ALDH1A1POLBHPGDKMT2ARORC | |
| SCHEMBL8280908 | 0.78 | FFAR4 (0.43) | IDO1TDO2HTR2BTP53TDP1 | |
| SCHEMBL10292484 | 0.78 | TRPA1 (0.56) | TRPA1LMNACHRM1SLC6A2ADRA1A | |
| SCHEMBL2975257 | 0.78 | TSHR (0.47) | TDP1ALOX15ALDH1A1MAPTPOLB | |
| SCHEMBL12695025 | 0.78 | TRPA1 (0.53) | TRPA1LMNATP53TDP1ALOX15 | |
| SCHEMBL2851014 | 0.78 | ALOX15 (0.37) | IDO1TDO2ALOX15MAPTALOX12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11802114-B2 | Compounds and methods for detection of superoxide | PROMEGA CORPORATION (US) | 2023-10-31 | — | — | US | disclosed |
| EP-2675812-B1 | CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2017-08-30 | — | — | EP | disclosed |
| US-20120245136-A1 | CHROMAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED | 2012-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245136-A1 | CHROMAN-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | KCNJ2, KCNJ1, KCNC1 | IDO1 3309/4885TDO2 4672/4885TRPA1 16/4885 |
| US-11802114-B2 | Compounds and methods for detection of superoxide | SOD1, GPX4, SOD3 | IDO1 2462/4885TDO2 705/4885TRPA1 2376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.