SCHEMBL12795331

SCHEMBL12795331

NS(=O)(=O)c1ccc2nsc(/N=N/c3ccc(O)c(Cl)c3)c2c1

nearest known ligand 0.61

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 4/20 0.61
PTGS1 P23219 4/20 0.61
BRD4 O60885 1/20 0.43
HSD17B10 Q99714 2/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP2C9 P11712 1/20 0.41
PHLPP2 Q6ZVD8 1/20 0.41
PLAU P00749 1/20 0.40
CDK1 P06493 2/20 0.40
CCNA2 P20248 2/20 0.40
CDK2 P24941 2/20 0.40
CA2 P00918 8/20 0.40
CA9 Q16790 7/20 0.40
CA12 O43570 5/20 0.40
GLO1 Q04760 4/20 0.40
CA1 P00915 5/20 0.39
CA7 P43166 1/20 0.39
ACHE P22303 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17514071 1.00 PTGS2 (0.61) PTGS2PTGS1BRD4HSD17B10ALDH1A1
SCHEMBL14517069 0.88 PTGS2 (0.48) PTGS2PTGS1BRD4HSD17B10PHLPP2
SCHEMBL18724507 0.87 CA2 (0.48) PTGS2PTGS1HSD17B10ALDH1A1CYP2C9
SCHEMBL13025293 0.84 PTGS2 (0.50) PTGS2PTGS1HSD17B10ALDH1A1CYP2C9
SCHEMBL14255045 0.84 PLAU (0.40) PTGS2PTGS1HSD17B10PLAUCDK1
SCHEMBL14517072 0.83 PTGS1 (0.41) PTGS2PTGS1BRD4HSD17B10ALDH1A1
SCHEMBL22269372 0.81 PTGS1 (0.40) PTGS2PTGS1BRD4ALDH1A1CDK1
SCHEMBL14517078 0.81 AMY1A (0.46) PTGS2PTGS1HSD17B10ALDH1A1CYP2C9
SCHEMBL13958614 0.81 PTGS1 (0.40) PTGS2PTGS1BRD4ALDH1A1
SCHEMBL12797898 0.80 CA1 (0.39) PTGS2PTGS1HSD17B10ALDH1A1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240068156-A1 FIBER-TREATING AGENT KAO CORPORATION (JP) 2024-02-29 US disclosed
US-20240068156-A1 FIBER-TREATING AGENT KAO CORPORATION (JP) 2024-02-29 US disclosed
EP-3685820-B1 LIQUID HAIR DYE COMPOSITION KAO CORP (JP) 2024-02-28 EP disclosed
EP-4268651-A1 FIBER-TREATING AGENT Kao Corporation (JP) 2023-11-01 EP disclosed
EP-4018864-A1 HUMAN HAIR FIBER TREATMENT AGENT Kao Corporation (JP) 2022-06-29 EP disclosed
US-20220151897-A1 LIQUID HAIR DYE COMPOSITION KAO CORPORATION (JP) 2022-05-19 US disclosed
EP-3943161-A1 LIQUID HAIR DYE COMPOSITION Kao Corporation (JP) 2022-01-26 EP disclosed
US-11090246-B2 Powder hair dye composition KAO CORPORATION (JP) 2021-08-17 US disclosed
US-11083678-B2 Hair dyeing method KAO CORPORATION (JP) 2021-08-10 US disclosed
US-11077042-B2 Liquid hair dye composition KAO CORPORATION (JP) 2021-08-03 US disclosed
US-20090049622-A1 HAIR DYE COMPOSITION KAO CORPORATION (JP) 2009-02-26 US disclosed
WO-2009005139-A2 HAIR DYE COMPOSITION KAO CORPORATION (JP) 2009-01-08 WO disclosed
WO-2008139985-A2 HAIR DYE COMPOSITION KAO CORPORATION (JP) 2008-11-20 WO disclosed
EP-1905421-A1 Hair dye composition Kao Corporation (JP) 2008-04-02 EP disclosed
EP-1847249-A1 HAIRDYE COMPOSITION Kao Corporation (JP) 2007-10-24 EP disclosed
US-20070157399-A1 HAIR DYE COMPOSITION KAO CORPORATION (JP) 2007-07-12 US disclosed
US-20070157399-A1 HAIR DYE COMPOSITION KAO CORPORATION (JP) 2007-07-12 US disclosed
EP-1803434-A1 Hair dye composition Kao Corporation (JP) 2007-07-04 EP disclosed
US-7198651-B2 Method of effecting a reversible color change of dyed hair KAO CORPORATION (JP) 2007-04-03 US disclosed
US-7198651-B2 Method of effecting a reversible color change of dyed hair KAO CORPORATION (JP) 2007-04-03 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070157399-A1 HAIR DYE COMPOSITION SMOX, AOC3, TYR PTGS2 2936/4885PTGS1 2244/4885BRD4 3443/4885
US-20220151897-A1 LIQUID HAIR DYE COMPOSITION S100B, HLA-B, LDHB PTGS2 4062/4885PTGS1 3825/4885BRD4 3834/4885
US-11077042-B2 Liquid hair dye composition HSD3B2, AHR, HSD11B2 PTGS2 2809/4885PTGS1 3901/4885BRD4 1991/4885
US-20090049622-A1 HAIR DYE COMPOSITION TYR, AR, AHR PTGS2 4756/4885PTGS1 4671/4885BRD4 155/4885
US-11083678-B2 Hair dyeing method HAO2, ALDH1A3, ALDH7A1 PTGS2 1259/4885PTGS1 1445/4885BRD4 4020/4885
US-11090246-B2 Powder hair dye composition H1-0, H1-3, H1-10 PTGS2 4512/4885PTGS1 4276/4885BRD4 3428/4885
US-20240068156-A1 FIBER-TREATING AGENT H1-5, H1-3, H1-4 PTGS2 3051/4885PTGS1 2434/4885BRD4 1196/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.