Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20239632 | 0.82 | LMNA (0.39) | LMNANR1I2ALDH1A1CYP1A2HTT | |
| SCHEMBL20239655 | 0.82 | LMNA (0.44) | LMNANR1I2ALDH1A1CYP1A2HTT | |
| SCHEMBL22917620 | 0.77 | TDP1 (0.42) | LMNANR1I2ALDH1A1CYP1A2HTT | |
| Dl-Dithiothreitol SCHEMBL21114401 | 0.73 | LMNA (0.44) | LMNANR1I2ALDH1A1CYP1A2HTT | |
| Dl-Dithiothreitol SCHEMBL17370231 | 0.73 | — | — | |
| Dl-Dithiothreitol SCHEMBL14496668 | 0.73 | — | — | |
| Dl-Dithiothreitol SCHEMBL87345 | 0.73 | — | — | |
| Dl-Dithiothreitol SCHEMBL21114400 | 0.73 | LMNA (0.44) | LMNANR1I2ALDH1A1CYP1A2HTT | |
| Dithiothreitol SCHEMBL538995 | 0.73 | — | — | |
| Dl-Dithiothreitol SCHEMBL10601 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8822146-B2 | Derivatization of biomolecules by covalent coupling of non-cofactor compounds using methyltransferases | VILNIUS UNIVERSITY (LT) | 2014-09-02 | — | — | US | disclosed |
| US-20120094280-A1 | DERIVATIZATION OF BIOMOLECULES BY COVALENT COUPLING OF NON-COFACTOR COMPOUNDS USING METHYLTRANSFERASES | BIOTECHNOLOGIJOS INSTITUTAS (LT) | 2012-04-19 | — | — | US | disclosed |
| US-20120088238-A1 | CONVERSION OF ALPHA-HYDROXYALKYLATED RESIDUES IN BIOMOLECULES USING METHYLTRANSFERASES | BIOTECHNOLOGIJOS INSTITUTAS (LT) | 2012-04-12 | — | — | US | disclosed |
| EP-0238441-B1 | Insecticidal proteinaceous substance | CIBA GEIGY AG (CH) | 1993-11-10 | — | — | EP | disclosed |
| EP-0238441-A2 | Insecticidal proteinaceous substance | CIBA-GEIGY AG (CH) | 1987-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088238-A1 | CONVERSION OF ALPHA-HYDROXYALKYLATED RESIDUES IN BIOMOLECULES USING METHYLTRANSFERASES | HNMT, SHMT1, BHMT | LMNA 477/4885NR1I2 2985/4885ALDH1A1 124/4885 |
| US-20120094280-A1 | DERIVATIZATION OF BIOMOLECULES BY COVALENT COUPLING OF NON-COFACTOR COMPOUNDS USING METHYLTRANSFERASES | EZH1, DOHH, BHMT2 | LMNA 464/4885NR1I2 2129/4885ALDH1A1 252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.