SCHEMBL1287360

SCHEMBL1287360

CC1(C)CC(NC(=O)C(=O)Nc2ccc(Br)cc2)CC(C)(C)N1

nearest known ligand 0.76

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.51
MEN1 O00255 2/20 0.51
KMT2A Q03164 2/20 0.51
NPSR1 Q6W5P4 1/20 0.51
MAPT P10636 2/20 0.50
LMNA P02545 1/20 0.50
GAA P10253 1/20 0.50
POLB P06746 3/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
NPC1 O15118 2/20 0.46
RAB9A P51151 2/20 0.46
EZH2 Q15910 1/20 0.45
HSD17B10 Q99714 1/20 0.44
HTT P42858 1/20 0.44
GLA P06280 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29196492 0.87 POLB (0.61) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL6790228 0.86 ALDH1A1 (0.51) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL1287379 0.86 MEN1 (0.52) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL2289255 0.86 GAA (0.62) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL6790089 0.84 KMT2A (0.55) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL15613206 0.83 HSD17B10 (0.48) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL6789510 0.83 HPGD (0.51) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL6787636 0.80 MEN1 (0.51) ALDH1A1MEN1KMT2ANPSR1GAA
SCHEMBL19414235 0.78 GAA (0.54) ALDH1A1MEN1KMT2ANPSR1MAPT
SCHEMBL3295977 0.78 RECQL (0.57) ALDH1A1MEN1KMT2AMAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140050793-A1 Novel Compositions for Inhibiting Virus Entry and Promoting Virolysis, and Methods Thereof DREXEL UNIVERSITY (US) 2014-02-20 US claimed
WO-2012048033-A2 NOVEL COMPOSITIONS FOR INHIBITING VIRUS ENTRY AND PROMOTING VIROLYISIS, AND METHODS THEREOF DREXEL UNIVERSITY (US) 2012-04-12 WO claimed
EP-4676493-A1 ASSAYS AND REAGENTS FOR THE DETECTION OF SOLUBLE GP120 Val-Chum, Limited Partnership (CA) 2026-01-14 EP disclosed
US-20260007628-A1 TREATMENT AND PREVENTION OF INFECTIONS USING VEGETABLE OIL-DERIVED POLYOLS THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2026-01-08 US disclosed
US-12440467-B2 Treatment and prevention of infections using vegetable oil-derived polyols THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2025-10-14 US disclosed
CN-115057911-B HIV inhibitor 广州朗圣药业有限公司 2025-01-03 CN disclosed
WO-2024182893-A1 ASSAYS AND REAGENTS FOR THE DETECTION OF SOLUBLE GP120 FINZI ANDRES (CA) 2024-09-12 WO disclosed
US-20240285790-A1 ANTIBODY-CD4 CONJUGATES AND METHODS OF USING THE SAME CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (CA) 2024-08-29 US disclosed
EP-4351647-A1 ANTIBODY-CD4 CONJUGATES AND METHODS OF USING THE SAME The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. (US) 2024-04-17 EP disclosed
US-20230181515-A1 TREATMENT AND PREVENTION OF INFECTIONS USING VEGETABLE OIL-DERIVED POLYOLS THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) 2023-06-15 US disclosed
WO-2022261406-A1 ANTIBODY-CD4 CONJUGATES AND METHODS OF USING THE SAME THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. (US) 2022-12-15 WO disclosed
US-20220380414-A1 COMPOSITIONS AND METHODS BASED ON HIV GP120 MUTANTS THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. 2022-12-01 US disclosed
CN-115057911-A HIV inhibitor 广州朗圣药业有限公司 2022-09-16 CN disclosed
CN-109824583-B Phenyl oxamide HIV-1 inhibitor and preparation method and application thereof 山东大学 2022-04-08 CN disclosed
US-9114107-B2 Compositions for inhibiting virus entry and promoting virolysis, and methods thereof DREXEL UNIVERSITY (US) 2015-08-25 US disclosed
US-9114107-B2 Compositions for inhibiting virus entry and promoting virolysis, and methods thereof DREXEL UNIVERSITY (US) 2015-08-25 US disclosed
US-20140050793-A1 Novel Compositions for Inhibiting Virus Entry and Promoting Virolysis, and Methods Thereof DREXEL UNIVERSITY (US) 2014-02-20 US disclosed
US-20140050793-A1 Novel Compositions for Inhibiting Virus Entry and Promoting Virolysis, and Methods Thereof DREXEL UNIVERSITY (US) 2014-02-20 US disclosed
WO-2012048033-A2 NOVEL COMPOSITIONS FOR INHIBITING VIRUS ENTRY AND PROMOTING VIROLYISIS, AND METHODS THEREOF DREXEL UNIVERSITY (US) 2012-04-12 WO disclosed
WO-2012048033-A2 NOVEL COMPOSITIONS FOR INHIBITING VIRUS ENTRY AND PROMOTING VIROLYISIS, AND METHODS THEREOF DREXEL UNIVERSITY (US) 2012-04-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12440467-B2 Treatment and prevention of infections using vegetable oil-derived polyols ELOVL3, TLR5, MGLL ALDH1A1 4552/4885MEN1 2686/4885KMT2A 2767/4885
US-20260007628-A1 TREATMENT AND PREVENTION OF INFECTIONS USING VEGETABLE OIL-DERIVED POLYOLS SARS1, ABHD6, FADS2 ALDH1A1 3891/4885MEN1 3989/4885KMT2A 4204/4885
US-20140050793-A1 Novel Compositions for Inhibiting Virus Entry and Promoting Virolysis, and Methods Thereof ZC3HAV1, ZC3HAV1L, CPN1 ALDH1A1 4793/4885MEN1 2876/4885KMT2A 4595/4885
US-20220380414-A1 COMPOSITIONS AND METHODS BASED ON HIV GP120 MUTANTS CD4, CCR5, TSG101 ALDH1A1 4869/4885MEN1 4616/4885KMT2A 4104/4885
US-20230181515-A1 TREATMENT AND PREVENTION OF INFECTIONS USING VEGETABLE OIL-DERIVED POLYOLS ELOVL3, TLR5, MGLL ALDH1A1 4552/4885MEN1 2686/4885KMT2A 2767/4885
US-20240285790-A1 ANTIBODY-CD4 CONJUGATES AND METHODS OF USING THE SAME CD4, FCGR3B, FCGR1A ALDH1A1 1703/4885MEN1 3686/4885KMT2A 3470/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.