Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 4/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 4/20 | 0.35 |
| ▸ | CA1 | P00915 | 4/20 | 0.35 |
| ▸ | CA2 | P00918 | 4/20 | 0.35 |
| ▸ | CA9 | Q16790 | 4/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19389074 | 1.00 | ABCB1 (0.39) | ABCB1MAOAACHEMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL28631036 | 0.99 | ABCB1 (0.38) | ABCB1MAOAACHEMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL28631038 | 0.99 | ABCB1 (0.38) | ABCB1MAOAACHEMAPTMEN1 | |
| SCHEMBL19740969 | 0.92 | MAOA (0.38) | ABCB1MAOAACHEMAPTMEN1 | |
| SCHEMBL10042788 | 0.87 | RAB9A (0.52) | ABCB1MAPTMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL20529544 | 0.86 | RAB9A (0.54) | ABCB1MAPTMEN1KMT2AALDH1A1 | |
| Hydrochloric Acid SCHEMBL20529546 | 0.86 | RAB9A (0.54) | ABCB1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL14765446 | 0.86 | ABCB1 (0.38) | ABCB1MAOAACHEMAPTMEN1 | |
| SCHEMBL29437960 | 0.85 | L3MBTL1 (0.38) | ABCB1ACHEALDH1A1TLR7HDAC1 | |
| SCHEMBL29437959 | 0.85 | L3MBTL1 (0.38) | ABCB1ACHEALDH1A1TLR7HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872157-B1 | CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS | HANGZHOU DAC BIOTECH CO LTD (CN) | 2020-01-22 | — | — | EP | disclosed |
| US-10399941-B2 | Conjugates of cell binding molecules with cytotoxic agents | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2019-09-03 | — | — | US | disclosed |
| EP-3348280-A1 | CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS | Hangzhou Dac Biotech Co., Ltd (CN) | 2018-07-18 | — | — | EP | disclosed |
| US-20180021448-A9 | Conjugates of Cell Binding Molecules with Cytotoxic Agents | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2018-01-25 | — | — | US | disclosed |
| US-20170296663-A1 | Conjugates of Cell Binding Molecules with Cytotoxic Agents | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2017-10-19 | — | — | US | disclosed |
| US-9771391-B2 | Process for preparing tubulysins | ENDOCYTE, INC. (US) | 2017-09-26 | — | — | US | disclosed |
| US-9771391-B2 | Process for preparing tubulysins | ENDOCYTE, INC. (US) | 2017-09-26 | — | — | US | disclosed |
| EP-3210627-A1 | CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS | Hangzhou Dac Biotech Co., Ltd (CN) | 2017-08-30 | — | — | EP | disclosed |
| US-20170157262-A1 | CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2017-06-08 | — | — | US | disclosed |
| US-9505747-B2 | Processes for preparing tubulysin derivatives and conjugates thereof | ENDOCYTE, INC. (US) | 2016-11-29 | — | — | US | disclosed |
| US-8889880-B2 | Processes for preparing tubulysins | ENDOCYTE, INC. (US) | 2014-11-18 | — | — | US | disclosed |
| US-20140249315-A1 | PROCESSES FOR PREPARING TUBULYSINS | ENDOCYTE, INC. | 2014-09-04 | — | — | US | disclosed |
| US-20140249315-A1 | PROCESSES FOR PREPARING TUBULYSINS | ENDOCYTE, INC. | 2014-09-04 | — | — | US | disclosed |
| WO-2014134543-A1 | PROCESSES FOR PREPARING TUBULYSINS | ENDOCYTE, INC. (US) | 2014-09-04 | — | — | WO | disclosed |
| US-20140080175-A1 | PROCESSES FOR PREPARING TUBULYSIN DERIVATIVES AND CONJUGATES THEREOF | ENDOCYTE, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| US-20140080175-A1 | PROCESSES FOR PREPARING TUBULYSIN DERIVATIVES AND CONJUGATES THEREOF | ENDOCYTE, INC. (US) | 2014-03-20 | — | — | US | disclosed |
| WO-2013149185-A1 | PROCESSES FOR PREPARING TUBULYSIN DERIVATIVES AND CONJUGATES THEREOF | ENDOCYTE, INC. (US) | 2013-10-03 | — | — | WO | disclosed |
| US-20130137139-A1 | PROCESSES FOR PREPARING TUBULYSINS | ENDOCYTE, INC. (US) | 2013-05-30 | — | — | US | disclosed |
| US-8394922-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | MEDAREX, INC. (US) | 2013-03-12 | — | — | US | disclosed |
| US-20110027274-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | MEDAREX, INC. (US) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140080175-A1 | PROCESSES FOR PREPARING TUBULYSIN DERIVATIVES AND CONJUGATES THEREOF | TEKT1, PTMS, TEK | ABCB1 2742/4885MAOA 2787/4885ACHE 4631/4885 |
| US-10399941-B2 | Conjugates of cell binding molecules with cytotoxic agents | CD4, CD2, CD47 | ABCB1 944/4885MAOA 4689/4885ACHE 4038/4885 |
| US-20170157262-A1 | CONJUGATES OF CELL BINDING MOLECULES WITH CYTOTOXIC AGENTS | CD4, CD2, CD47 | ABCB1 973/4885MAOA 4558/4885ACHE 4158/4885 |
| US-20140249315-A1 | PROCESSES FOR PREPARING TUBULYSINS | LGMN, REN, MAN2B2 | ABCB1 3964/4885MAOA 3642/4885ACHE 4388/4885 |
| US-20110027274-A1 | ANTIPROLIFERATIVE COMPOUNDS, CONJUGATES THEREOF, METHODS THEREFOR, AND USES THEREOF | WEE1, NGLY1, CD81 | ABCB1 741/4885MAOA 4477/4885ACHE 4365/4885 |
| US-20180021448-A9 | Conjugates of Cell Binding Molecules with Cytotoxic Agents | CD4, CD2, CD47 | ABCB1 944/4885MAOA 4689/4885ACHE 4038/4885 |
| US-20170296663-A1 | Conjugates of Cell Binding Molecules with Cytotoxic Agents | CD4, CD2, CD47 | ABCB1 944/4885MAOA 4689/4885ACHE 4038/4885 |
| US-20130137139-A1 | PROCESSES FOR PREPARING TUBULYSINS | NGLY1, LGMN, TEKT1 | ABCB1 2967/4885MAOA 3686/4885ACHE 4647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.