SCHEMBL1292012

SCHEMBL1292012

Nc1ccc2nnsc2c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.46
PTPN11 Q06124 1/20 0.43
MAPT P10636 6/20 0.43
NPC1 O15118 3/20 0.43
RAB9A P51151 3/20 0.43
KDM4E B2RXH2 3/20 0.43
GLA P06280 3/20 0.43
GAA P10253 3/20 0.43
ALDH1A1 P00352 3/20 0.42
POLB P06746 2/20 0.42
KEAP1 Q14145 1/20 0.42
BAZ1A Q9NRL2 3/20 0.41
PKM P14618 2/20 0.41
HPGD P15428 2/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA4 P22748 1/20 0.41
TP53 P04637 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL660021 0.83 THRB (0.46) SMN1; SMN2PTPN11MAPTNPC1RAB9A
SCHEMBL10630197 0.74 BAZ1A (0.47) SMN1; SMN2MAPTNPC1RAB9AKDM4E
SCHEMBL2211494 0.74 ALDH1A1 (0.46) MAPTNPC1RAB9AKDM4EGAA
SCHEMBL1291431 0.74 NPC1 (0.42) MAPTNPC1RAB9AALDH1A1POLB
SCHEMBL14582771 0.73 THRB (0.42) SMN1; SMN2MAPTNPC1RAB9AKDM4E
SCHEMBL1291502 0.71 NSD2 (0.59) SMN1; SMN2NPC1RAB9AALDH1A1BAZ1A
Benzene SCHEMBL28730813 0.70 MAPT (0.39) SMN1; SMN2MAPTNPC1RAB9AKDM4E
SCHEMBL10634714 0.69 PRMT3 (0.51) MAPTNPC1RAB9AKDM4EALDH1A1
SCHEMBL507524 0.69 PRMT3 (0.45) MAPTNPC1RAB9AALDH1A1POLB
SCHEMBL29567889 0.69 PRMT3 (0.45) MAPTNPC1RAB9AALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117865912-B AQP9 inhibitor and preparation method and application thereof 康替生物科技(杭州)有限公司 2025-03-11 CN claimed
CN-117865912-A AQP9 inhibitor and preparation method and application thereof 康替生物科技(杭州)有限公司 2024-04-12 CN claimed
CN-117865912-B AQP9 inhibitor and preparation method and application thereof 康替生物科技(杭州)有限公司 2025-03-11 CN disclosed
CN-117865912-A AQP9 inhibitor and preparation method and application thereof 康替生物科技(杭州)有限公司 2024-04-12 CN disclosed
US-20200079786-A1 ANALOGS OF ADAMANTYLUREAS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS UNIVERSITAT DE BARCELONA (ES) 2020-03-12 US disclosed
US-20190322632-A1 HRI ACTIVATORS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES UNIVERSITAT DE BARCELONA (ES) 2019-10-24 US disclosed
US-20190322632-A1 HRI ACTIVATORS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES UNIVERSITAT DE BARCELONA (ES) 2019-10-24 US disclosed
EP-3328854-A1 ANALOGS OF ADAMANTYLUREAS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS Universitat de Barcelona (ES) 2018-06-06 EP disclosed
US-9920044-B2 Selective androgen receptor modulators RADIUS PHARMACEUTICALS, INC. (US) 2018-03-20 US disclosed
US-9920044-B2 Selective androgen receptor modulators RADIUS PHARMACEUTICALS, INC. (US) 2018-03-20 US disclosed
US-9920044-B2 Selective androgen receptor modulators RADIUS PHARMACEUTICALS, INC. (US) 2018-03-20 US disclosed
US-20030095914-A1 In the absence of an externally applied electric current sufficient to reduce the diazonium salt and attach an organic group; improved abrasion resistance. BELMONT JAMES A (US) 2003-05-22 US disclosed
US-6494946-B1 PROCESSES FOR PREPARING A CARBON BLACK PRODUCT HAVING AN ORGANIC GROUP ATTACHED TO THE CARBON BLACK. IN ONE PROCESS AT LEAST ONE DIAZONIUM SALT REACTS WITH A CARBON BLACK IN THE ABSENCE OF AN EXTERNALLY APPLIED ELECTRIC CURRENT SUFFICIENT CABOT CORPORATION 2002-12-17 US disclosed
EP-0799281-B1 CARBON BLACK REACTED WITH DIAZONIUM SALTS AND PRODUCTS CABOT CORP (US) 2002-07-24 EP disclosed
EP-1225205-A2 Carbon black reacted with diazonium salts and products CABOT CORPORATION (US) 2002-07-24 EP disclosed
US-6042643-A AS PIGMENT TO COLOR PLASTICS, PAPER, TEXTILE, RUBBER, AQUEOUS INKS CABOT CORPORATION (US) 2000-03-28 US disclosed
US-5900029-A COLORING FIBER OR TEXTILE CABOT CORPORATION (US) 1999-05-04 US disclosed
US-5851280-A Reaction of carbon black with diazonium salts, resultant carbon black products and their uses CABOT CORPORATION (US) 1998-12-22 US disclosed
EP-0799281-A1 CARBON BLACK REACTED WITH DIAZONIUM SALTS AND PRODUCTS CABOT CORPORATION (US) 1997-10-08 EP disclosed
WO-1996018688-A1 CARBON BLACK REACTED WITH DIAZONIUM SALTS AND PRODUCTS CABOT CORPORATION (US) 1996-06-20 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200079786-A1 ANALOGS OF ADAMANTYLUREAS AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS EPHX1, EPHX2, NCEH1 SMN1; SMN2 3579/4885PTPN11 3218/4885MAPT 4551/4885
US-20190322632-A1 HRI ACTIVATORS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES NR1I2, HMOX1, HMOX2 SMN1; SMN2 3966/4885PTPN11 3210/4885MAPT 4849/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.