Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.43 |
| ▸ | MAPT | P10636 | 10/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | G6PC1 | P35575 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12869222 | 1.00 | MEN1 (0.43) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL13043594 | 0.91 | MEN1 (0.39) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL13694853 | 0.90 | MEN1 (0.42) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL2920143 | 0.87 | MEN1 (0.46) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL2921507 | 0.87 | ACHE (0.47) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL2920142 | 0.87 | MEN1 (0.46) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL2921302 | 0.87 | ACHE (0.47) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL2920802 | 0.85 | MEN1 (0.47) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL10037523 | 0.85 | MEN1 (0.45) | MEN1KMT2AMAPTSMN1; SMN2NPC1 | |
| SCHEMBL3024010 | 0.85 | MEN1 (0.47) | MEN1KMT2AMAPTSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2677996-B1 | COMPOSITION FOR DYEING KERATINOUS FIBRES COMPRISING A DIRECT DYE HAVING A DISULPHIDE/THIOL FUNCTIONAL GROUP, A THICKENING POLYMER, AN ETHOXYLATED FATTY ALCOHOL AND/OR A NONIONIC SURFACTANT, AN ALKALINE AGENT AND A REDUCING AGENT | L'ORÉAL (FR) | 2017-11-29 | — | — | EP | disclosed |
| US-9522106-B2 | Composition for dyeing keratinous fibres comprising a direct dye having a disulphide/thiol functional group, a thickening polymer, an ethoxylated fatty alcohol and/or a nonionic surfactant, an alkaline agent and a reducing agent | L'OREAL (FR) | 2016-12-20 | — | — | US | disclosed |
| US-9345652-B2 | Composition for dyeing keratin fibres comprising a direct dye bearing a disulphide/thiol function, a sparingly or non-ethoxylated fatty alcohol, a cationic surfactant, an alkaline agent and a reducing agent | L'OREAL (FR) | 2016-05-24 | — | — | US | disclosed |
| US-9271915-B2 | Composition for dyeing keratin fibres comprising a direct dye bearing a disulphide/thiol function, a non-cellulose-based thickening polymer, an alkaline agent and a reducing agent | L'OREAL (FR) | 2016-03-01 | — | — | US | disclosed |
| US-9265705-B2 | Composition for dyeing keratin fibres comprising a direct dye bearing a disulphide/thiol function, a nonionic surfactant, an amphoteric surfactant, an ethoxylated fatty alcohol, an alkaline agent and a reducing agent | L'OREAL (FR) | 2016-02-23 | — | — | US | disclosed |
| US-8840684-B2 | Process for dyeing keratin fibres using a direct dye bearing a disulfide/thiol/protected thiol function and water vapour | L'OREAL (FR) | 2014-09-23 | — | — | US | disclosed |
| US-20140137342-A1 | COMPOSITION FOR DYEING KERATIN FIBRES COMPRISING A DIRECT DYE BEARING A DISULPHIDE/THIOL FUNCTION, A NONIONIC SURFACTANT, AN AMPHOTERIC SURFACTANT, AN ETHOXYLATED FATTY ALCOHOL, AN ALKALINE AGENT AND A REDUCING AGENT | L'OREAL (FR) | 2014-05-22 | — | — | US | disclosed |
| US-20140075687-A1 | COMPOSITION FOR DYEING KERATINOUS FIBRES COMPRISING A DIRECT DYE HAVING A DISULPHIDE/THIOL FUNCTIONAL GROUP, A THICKENING POLYMER, AN ETHOXYLATED FATTY ALCOHOL AND/OR A NONIONIC SURFACTANT, AN ALKALINE AGENT AND A REDUCING AGENT | L'OREAL (FR) | 2014-03-20 | — | — | US | disclosed |
| US-20140041132-A1 | COMPOSITION FOR DYEING KERATIN FIBRES COMPRISING A DIRECT DYE BEARING A DISULPHIDE/THIOL FUNCTION, A NON-CELLULOSE-BASED THICKENING POLYMER, AN ALKALINE AGENT AND A REDUCING AGENT | L'OREAL (FR) | 2014-02-13 | — | — | US | disclosed |
| EP-2075036-B1 | COMPOSITION FOR DYEING KERATIN CONTAINING FIBRES COMPRISING DISULFIDE DYES AND METHOD | BASF SE (DE) | 2013-11-06 | — | — | EP | disclosed |
| US-20130283544-A1 | PROCESS FOR DYEING KERATIN FIBRES USING A DIRECT DYE BEARING A DISULFIDE/THIOL/PROTECTED THIOL FUNCTION AND WATER VAPOUR | L'OREAL (FR) | 2013-10-31 | — | — | US | disclosed |
| US-7828858-B2 | Mixture of sulfide dyes | CIBA CORPORATION (US) | 2010-11-09 | — | — | US | disclosed |
| EP-2075036-A1 | Disulfid dyes, composition comprising them and method of dyeing hair | Ciba Holding Inc. (CH) | 2009-07-01 | — | — | EP | disclosed |
| US-20090100610-A1 | Mixture of Sulfide Dyes | CIBA CORPORATION | 2009-04-23 | — | — | US | disclosed |
| US-7488354-B2 | Dyeing composition comprising at least one disulphide dye and method of dyeing human keratin fibers using this dye | L'OREAL S.A. (FR) | 2009-02-10 | — | — | US | disclosed |
| US-7476260-B2 | Disulfide dyes, composition comprising them and method of dyeing hair | CIBA SPECIALTY CHEMICALS CORP. (US) | 2009-01-13 | — | — | US | disclosed |
| US-20080295260-A1 | Disulfide Dyes, Composition Comprising them and Method of Dyeing Hair | CIBA SPECIALTY CHEMICALS CORP. | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130283544-A1 | PROCESS FOR DYEING KERATIN FIBRES USING A DIRECT DYE BEARING A DISULFIDE/THIOL/PROTECTED THIOL FUNCTION AND WATER VAPOUR | KRT18, TST, PDIA5 | MEN1 4799/4885KMT2A 2864/4885MAPT 322/4885 |
| US-20090100610-A1 | Mixture of Sulfide Dyes | KRT18, TST, ARSA | MEN1 4052/4885KMT2A 2892/4885MAPT 1174/4885 |
| US-20140137342-A1 | COMPOSITION FOR DYEING KERATIN FIBRES COMPRISING A DIRECT DYE BEARING A DISULPHIDE/THIOL FUNCTION, A NONIONIC SURFACTANT, AN AMPHOTERIC SURFACTANT, AN ETHOXYLATED FATTY ALCOHOL, AN ALKALINE AGENT AND A REDUCING AGENT | KRT18, ANXA4, S100A4 | MEN1 4449/4885KMT2A 1743/4885MAPT 2113/4885 |
| US-20080295260-A1 | Disulfide Dyes, Composition Comprising them and Method of Dyeing Hair | STS, CYP2S1, SQOR | MEN1 2919/4885KMT2A 4209/4885MAPT 4591/4885 |
| US-20140041132-A1 | COMPOSITION FOR DYEING KERATIN FIBRES COMPRISING A DIRECT DYE BEARING A DISULPHIDE/THIOL FUNCTION, A NON-CELLULOSE-BASED THICKENING POLYMER, AN ALKALINE AGENT AND A REDUCING AGENT | KRT18, DSG1, KLK5 | MEN1 4294/4885KMT2A 1290/4885MAPT 990/4885 |
| US-20140075687-A1 | COMPOSITION FOR DYEING KERATINOUS FIBRES COMPRISING A DIRECT DYE HAVING A DISULPHIDE/THIOL FUNCTIONAL GROUP, A THICKENING POLYMER, AN ETHOXYLATED FATTY ALCOHOL AND/OR A NONIONIC SURFACTANT, AN ALKALINE AGENT AND A REDUCING AGENT | KRT18, ESD, ADH5 | MEN1 4690/4885KMT2A 1426/4885MAPT 1257/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.