Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 4/20 | 0.67 |
| ▸ | MEN1 | O00255 | 3/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.67 |
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | PLEC | Q15149 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | ALPL | P05186 | 2/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.51 |
| ▸ | ALPG | P10696 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 11/20 | 0.48 |
| ▸ | CA1 | P00915 | 9/20 | 0.48 |
| ▸ | CA2 | P00918 | 9/20 | 0.48 |
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 1/20 | 0.47 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17088308 | 0.88 | MEN1 (0.49) | USP2MEN1KMT2APOLBATM | |
| SCHEMBL7970133 | 0.87 | USP2 (0.54) | USP2MEN1KMT2APOLBATM | |
| SCHEMBL19564789 | 0.86 | USP2 (0.58) | USP2MEN1KMT2APOLBATM | |
| SCHEMBL13045911 | 0.85 | USP2 (0.48) | USP2MEN1KMT2APOLBATM | |
| SCHEMBL26351340 | 0.84 | USP2 (0.60) | USP2MEN1KMT2APOLBATM | |
| SCHEMBL17089150 | 0.84 | USP2 (0.53) | USP2MEN1KMT2APOLBATM | |
| SCHEMBL8930410 | 0.84 | MEN1 (0.74) | USP2MEN1KMT2APOLBATM | |
| SCHEMBL13211048 | 0.84 | USP2 (0.55) | USP2MEN1KMT2APOLBATM | |
| SCHEMBL12677052 | 0.83 | USP2 (0.54) | USP2MEN1KMT2APOLBATM | |
| SCHEMBL19569732 | 0.83 | USP2 (0.59) | USP2MEN1KMT2APOLBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2023-05-11 | — | — | US | disclosed |
| US-11325884-B2 | Ketone inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2022-05-10 | — | — | US | disclosed |
| US-20210053908-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2021-02-25 | — | — | US | disclosed |
| US-10730826-B2 | Ketone inhibitors of lysine gingipain | Cortexyme, Inc. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20200174008-A1 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS | WATERS TECHNOLOGIES CORPORATION | 2020-06-04 | — | — | US | disclosed |
| US-10436790-B2 | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals | WATERS TECHNOLOGIES CORPORATION (US) | 2019-10-08 | — | — | US | disclosed |
| US-10416166-B2 | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals | WATERS TECHNOLOGIES CORPORATION (US) | 2019-09-17 | — | — | US | disclosed |
| US-20190210960-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2019-07-11 | — | — | US | disclosed |
| US-10006918-B2 | Fluorogenic hydrazine-substituted compounds | Life Technologies Corporation (US) | 2018-06-26 | — | — | US | disclosed |
| US-8772487-B2 | Fluorogenic hydrazine-substituted compounds | Life Technologies Corporation (US) | 2014-07-08 | — | — | US | disclosed |
| US-8772487-B2 | Fluorogenic hydrazine-substituted compounds | Life Technologies Corporation (US) | 2014-07-08 | — | — | US | disclosed |
| US-20140179011-A1 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS | WATERS TECHNOLOGIES CORPORATION (US) | 2014-06-26 | — | — | US | disclosed |
| US-20140179011-A1 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS | WATERS TECHNOLOGIES CORPORATION (US) | 2014-06-26 | — | — | US | disclosed |
| US-20130288911-A1 | FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS | Life Technologies Corporation | 2013-10-31 | — | — | US | disclosed |
| US-20130288911-A1 | FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS | Life Technologies Corporation | 2013-10-31 | — | — | US | disclosed |
| WO-2013049622-A1 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS | WATERS TECHNOLOGIES CORPORATION (US) | 2013-04-04 | — | — | WO | disclosed |
| US-20100291547-A1 | FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS | Life Technologies Corporation (US) | 2010-11-18 | — | — | US | disclosed |
| US-20100291547-A1 | FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS | Life Technologies Corporation (US) | 2010-11-18 | — | — | US | disclosed |
| WO-2009094536-A1 | FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS | Life Technologies Corporation (US) | 2009-07-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210053908-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | PHYKPL, ENPEP, PREP | USP2 2707/4885MEN1 1912/4885KMT2A 300/4885 |
| US-10416166-B2 | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals | FUT5, FUT6, CSGALNACT1 | USP2 2653/4885MEN1 1968/4885KMT2A 2567/4885 |
| US-20230142714-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | PHYKPL, ENPEP, PREP | USP2 2707/4885MEN1 1912/4885KMT2A 300/4885 |
| US-10730826-B2 | Ketone inhibitors of lysine gingipain | PHYKPL, ENPEP, PREP | USP2 2707/4885MEN1 1912/4885KMT2A 300/4885 |
| US-20200174008-A1 | RAPID FLUORESCENCE TAGGING OF GLYCANS AND OTHER BIOMOLECULES WITH ENHANCED MS SIGNALS | FUT5, FUT6, CSGALNACT1 | USP2 2267/4885MEN1 2746/4885KMT2A 3081/4885 |
| US-20190210960-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | PHYKPL, ENPEP, PREP | USP2 2707/4885MEN1 1912/4885KMT2A 300/4885 |
| US-20100291547-A1 | FLUOROGENIC HYDRAZINE-SUBSTITUTED COMPOUNDS | ALDH2, ALDH1A2, HLCS | USP2 3504/4885MEN1 2294/4885KMT2A 2025/4885 |
| US-11325884-B2 | Ketone inhibitors of lysine gingipain | PHYKPL, ENPEP, PREP | USP2 2707/4885MEN1 1912/4885KMT2A 300/4885 |
| US-10006918-B2 | Fluorogenic hydrazine-substituted compounds | ALDH2, ALDH1A2, HLCS | USP2 3504/4885MEN1 2294/4885KMT2A 2025/4885 |
| US-10436790-B2 | Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals | FUT5, FUT6, CSGALNACT1 | USP2 1661/4885MEN1 2175/4885KMT2A 2419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.