SCHEMBL13058820

SCHEMBL13058820

COc1c(C)c2c(c(O)c1C/C=C(\C)CCC(C)=O)C(=O)OC2

nearest known ligand 0.86

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ IMPDH2 P12268 20/20 0.86
▸ IMPDH1 P20839 14/20 0.86
▸ KDM4E B2RXH2 1/20 0.86
▸ ALDH1A1 P00352 1/20 0.86
▸ LMNA P02545 1/20 0.86
▸ CYP1A2 P05177 1/20 0.86
▸ CYP3A4 P08684 1/20 0.86
▸ HPGD P15428 1/20 0.86
▸ UGT2B7 P16662 1/20 0.86
▸ SMN1; SMN2 Q16637 1/20 0.86
▸ HSD17B10 Q99714 1/20 0.86
▸ HDAC3 O15379 2/20 0.81
▸ HDAC4 P56524 2/20 0.81
▸ HDAC1 Q13547 2/20 0.81
▸ HDAC7 Q8WUI4 2/20 0.81
▸ HDAC2 Q92769 2/20 0.81
▸ HDAC10 Q969S8 2/20 0.81
▸ HDAC11 Q96DB2 2/20 0.81
▸ HDAC8 Q9BY41 2/20 0.81
▸ HDAC6 Q9UBN7 2/20 0.81

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Mycophenolic Acid SCHEMBL5259872 0.92 IMPDH2 (1.00) IMPDH2IMPDH1KDM4EALDH1A1LMNA
Mycophenolic Acid SCHEMBL5500098 0.92 IMPDH2 (1.00) IMPDH2IMPDH1KDM4EALDH1A1LMNA
Mycophenolic Acid SCHEMBL2514376 0.92 IMPDH2 (1.00) IMPDH2IMPDH1KDM4EALDH1A1LMNA
Mycophenolic Acid SCHEMBL1657813 0.92 IMPDH2 (1.00) IMPDH2IMPDH1KDM4EALDH1A1LMNA
Mycophenolic Acid SCHEMBL1230249 0.92 IMPDH2 (1.00) IMPDH2IMPDH1KDM4EALDH1A1LMNA
Mycophenolic Acid SCHEMBL29645054 0.92 IMPDH2 (1.00) IMPDH2IMPDH1KDM4EALDH1A1LMNA
Mycophenolic Acid SCHEMBL29380425 0.92 IMPDH2 (1.00) IMPDH2IMPDH1KDM4EALDH1A1LMNA
Mycophenolic Acid SCHEMBL4549 0.92 IMPDH2 (1.00) IMPDH2IMPDH1KDM4EALDH1A1LMNA
SCHEMBL1375645 0.91 IMPDH2 (1.00) IMPDH2IMPDH1KDM4EALDH1A1LMNA
SCHEMBL18538601 0.91 IMPDH2 (0.82) IMPDH2IMPDH1KDM4EALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230285435-A1 COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2023-09-14 — — US disclosed
US-20230144779-A1 FORMULATIONS AND METHOD FOR TREATMENT OF INFLAMMATORY DISEASES VYOME THERAPEUTICS INC. (US) 2023-05-11 — — US disclosed
US-20170050945-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF SARCOIDOSIS INSMED INCORPORTED 2017-02-23 — — US disclosed
WO-2014068506-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF AUTOIMMUNE DISEASES KANDULA MAHESH (IN) 2014-05-08 — — WO disclosed
US-20100298560-A1 PROCESS FOR PREPARING MYCOPHENOLATE MOFETIL CKD BIO CORP. (KR) 2010-11-25 — — US disclosed
US-20080171724-A1 Phosphonate Derivatives of Mycophenolic Acid GILEAD SCIENCES, INC. (US) 2008-07-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230285435-A1 COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS EIF2AK2, RNGTT, ADAR IMPDH2 497/4885IMPDH1 530/4885KDM4E 1666/4885
US-20170050945-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF SARCOIDOSIS TNF, SMURF1, TPMT IMPDH2 455/4885IMPDH1 381/4885KDM4E 2269/4885
US-20080171724-A1 Phosphonate Derivatives of Mycophenolic Acid PPP5C, DUSP15, DUSP4 IMPDH2 615/4885IMPDH1 446/4885KDM4E 1913/4885
US-20230144779-A1 FORMULATIONS AND METHOD FOR TREATMENT OF INFLAMMATORY DISEASES UACA, TNF, TPMT IMPDH2 575/4885IMPDH1 469/4885KDM4E 1361/4885
US-20100298560-A1 PROCESS FOR PREPARING MYCOPHENOLATE MOFETIL TPMT, MYCBP2, TET2 IMPDH2 33/4885IMPDH1 60/4885KDM4E 35/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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