Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 known ✓ | P00915 | 2/20 | 0.50 |
| ▸ | CA2 known ✓ | P00918 | 2/20 | 0.50 |
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.42 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.50 |
| ▸ | MMP1 | P03956 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | MMP8 | P22894 | 1/20 | 0.50 |
| ▸ | MMP13 | P45452 | 1/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6912736 | 0.94 | MMP2 (0.50) | MMP2CA1CA2MMP1MMP9 | |
| SCHEMBL6918587 | 0.94 | MMP2 (0.50) | MMP2CA1CA2MMP1MMP9 | |
| SCHEMBL6914789 | 0.94 | MMP2 (0.50) | MMP2CA1CA2MMP1MMP9 | |
| Zinc Ion SCHEMBL6913980 | 0.94 | MMP2 (0.50) | MMP2CA1CA2MMP1MMP9 | |
| Silver SCHEMBL6114752 | 0.94 | MMP2 (0.50) | MMP2CA1CA2MMP1MMP9 | |
| SCHEMBL6918598 | 0.94 | MMP2 (0.50) | MMP2CA1CA2MMP1MMP9 | |
| SCHEMBL6916643 | 0.94 | MMP2 (0.50) | MMP2CA1CA2MMP1MMP9 | |
| SCHEMBL6909664 | 0.94 | MMP2 (0.50) | MMP2CA1CA2MMP1MMP9 | |
| SCHEMBL6914532 | 0.94 | MMP2 (0.50) | MMP2CA1CA2MMP1MMP9 | |
| Lithium Ion SCHEMBL16563321 | 0.87 | MMP2 (0.45) | MMP2CA1CA2MMP1MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116375907-A | Method for producing sugammadex | 默沙东有限责任公司 | 2023-07-04 | — | — | CN | claimed |
| CN-115010926-B | Polysulfone resin and preparation method thereof | 中国科学院长春应用化学研究所 | 2023-06-20 | — | — | CN | claimed |
| US-20210206884-A1 | PROCESSES FOR THE PREPARATION OF SUGAMMADEX | MERCK SHARP & DOHME CORP. (US) | 2021-07-08 | — | — | US | claimed |
| EP-3802627-A1 | PROCESSES FOR THE PREPARATION OF SUGAMMADEX | Merck Sharp & Dohme Corp. (US) | 2021-04-14 | — | — | EP | claimed |
| CN-112449642-A | Process for preparing sugammadex | 默沙东公司 | 2021-03-05 | — | — | CN | claimed |
| CN-116375907-A | Method for producing sugammadex | 默沙东有限责任公司 | 2023-07-04 | — | — | CN | disclosed |
| CN-115010926-B | Polysulfone resin and preparation method thereof | 中国科学院长春应用化学研究所 | 2023-06-20 | — | — | CN | disclosed |
| US-11634511-B2 | Processes for the preparation of sugammadex | MERCK SHARP & DOHME LLC (US) | 2023-04-25 | — | — | US | disclosed |
| CN-113527146-B | Method for preparing beta-hydroxy-difluoro sulfonyl ester compound by promoting hydroxylation sulfonyl esterification reaction of difluoro alkene by molecular oxygen | 广东药科大学 | 2023-04-18 | — | — | CN | disclosed |
| CN-113387855-B | Method for synthesizing disulfide compound by visible light and titanocene complex concerted catalysis | 陕西师范大学 | 2023-04-14 | — | — | CN | disclosed |
| CN-113372251-B | Method for synthesizing thioester by cross coupling of sodium sulfinate and acyl chloride under catalysis of visible light | 陕西师范大学 | 2023-04-14 | — | — | CN | disclosed |
| CN-111943925-B | Synthesis method of chromanone compounds | 吉林警察学院 | 2023-04-14 | — | — | CN | disclosed |
| CN-111087366-A | β -aryl sulfonyl enamine compound synthesis method | 湖南农业大学 | 2020-05-01 | — | — | CN | disclosed |
| CN-110862354-A | Bifunctional 1,2, 3-triazole derivative intermediate, preparation method and application | 山东师范大学 | 2020-03-06 | — | — | CN | disclosed |
| US-20190276603-A1 | POLY(2,6-DIMETHYL-1,4-PHENYLENE-OXIDE) DERIVATIVES WITH SULFONYL PENDANT GROUPS AND METHODS THEREFOR | GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 2019-09-12 | — | — | US | disclosed |
| US-10364324-B2 | Poly(2,6-dimethyl-1,4-phenylene-oxide) derivatives with sulfonyl pendant groups and methods therefor | The United States of Ameirca as represented by the Secretary of the Air Force (US) | 2019-07-30 | — | — | US | disclosed |
| US-20190055355-A1 | POLY(2,6-DIMETHYL-1,4-PHENYLENE-OXIDE) DERIVATIVES WITH SULFONYL PENDANT GROUPS AND METHODS THEREFOR | GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE AIR FORCE (US) | 2019-02-21 | — | — | US | disclosed |
| CN-105481806-B | The synthetic method of the 5-membered ring compounds containing sulfuryl and application | 华南理工大学 | 2018-09-14 | — | — | CN | disclosed |
| US-8053091-B2 | Hyperbranched polymer, organic light-emitting diode including organic layer including the hyperbranched polymer, and method of manufacturing the organic light-emitting diode | SAMSUNG MOBILE DISPLAY CO., LTD. (KR) | 2011-11-08 | — | — | US | disclosed |
| US-20080290338-A1 | Hyperbranched polymer, organic light-emitting diode including organic layer including the hyperbranched polymer, and method of manufacturing the organic light-emitting diode | SAMSUNG DISPLAY CO., LTD. (KR) | 2008-11-27 | — | — | US | disclosed |