SCHEMBL1317879

SCHEMBL1317879

COc1ccccc1-c1ccc(C(=O)O)c(NC(=O)c2cncc(-c3ccccc3)c2)c1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ACLY P53396 2/20 0.50
CTSA P10619 1/20 0.48
ALDH1A1 P00352 1/20 0.47
CHEK1 O14757 1/20 0.47
PIM1 P11309 1/20 0.47
MAPK8 P45983 1/20 0.47
CLK4 Q9HAZ1 1/20 0.47
DHODH Q02127 3/20 0.46
XDH P47989 2/20 0.46
LMNA P02545 1/20 0.46
RAB9A P51151 1/20 0.46
KDM4C Q9H3R0 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
HDAC6 Q9UBN7 1/20 0.45
MAPT P10636 1/20 0.45
ABCB1 P08183 1/20 0.44
NPSR1 Q6W5P4 1/20 0.44
TP53 P04637 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1317586 0.91 ACLY (0.51) ACLYALDH1A1CHEK1PIM1MAPK8
SCHEMBL1316037 0.89 CTSA (0.45) CTSAALDH1A1DHODHLMNAHDAC1
SCHEMBL1316295 0.88 ALDH1A1 (0.47) ACLYALDH1A1DHODHXDHLMNA
SCHEMBL1318129 0.88 MKNK1 (0.49) ACLYALDH1A1DHODHXDH
SCHEMBL15127674 0.87 ACLY (0.47) ACLYALDH1A1DHODHXDHHDAC1
SCHEMBL12118092 0.86 ACLY (0.52) ACLYCTSAALDH1A1DHODHXDH
SCHEMBL1316613 0.86 SCN10A (0.49) ACLYALDH1A1DHODH
SCHEMBL13206565 0.86 ACLY (0.44) ACLYALDH1A1DHODHXDHHDAC1
SCHEMBL2273065 0.86 MAPK1 (0.57) ACLYALDH1A1CHEK1PIM1MAPK8
SCHEMBL1315751 0.86 ACLY (0.64) ACLYALDH1A1DHODHXDHKDM4C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 ACLY 295/4885CTSA 923/4885ALDH1A1 813/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.