SCHEMBL1317586

SCHEMBL1317586

COc1cccc(-c2ccc(C(=O)O)c(NC(=O)c3cncc(-c4ccccc4)c3)c2)c1OC.[NaH]

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACLY P53396 2/20 0.51
ABCB1 P08183 6/20 0.46
MAPT P10636 1/20 0.44
STIM1 Q13586 1/20 0.43
ORAI1 Q96D31 1/20 0.43
ALDH1A1 P00352 3/20 0.43
CHEK1 O14757 1/20 0.43
PIM1 P11309 1/20 0.43
MAPK8 P45983 1/20 0.43
CLK4 Q9HAZ1 1/20 0.43
USP2 O75604 1/20 0.42
SIRT2 Q8IXJ6 1/20 0.42
XDH P47989 1/20 0.42
ABCC1 P33527 1/20 0.42
LMNA P02545 2/20 0.42
MEN1 O00255 1/20 0.42
HPGD P15428 1/20 0.42
HTT P42858 1/20 0.42
KMT2A Q03164 1/20 0.42
RAB9A P51151 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1317879 0.91 ACLY (0.50) ACLYABCB1MAPTALDH1A1CHEK1
SCHEMBL1317585 0.91 ABCB1 (0.44) ACLYABCB1MAPTALDH1A1USP2
SCHEMBL1318129 0.84 MKNK1 (0.49) ACLYALDH1A1XDH
SCHEMBL1316295 0.84 ALDH1A1 (0.47) ACLYMAPTALDH1A1XDHLMNA
SCHEMBL1315613 0.84 HDAC2 (0.56) ACLYALDH1A1XDHMEN1KMT2A
SCHEMBL1318785 0.83 PRSS12 (0.55) ACLYABCB1ALDH1A1XDHMEN1
SCHEMBL1317201 0.83 ACLY (0.51) ACLYALDH1A1XDHRAB9A
SCHEMBL1316095 0.82 ACLY (0.52) ACLYALDH1A1XDH
SCHEMBL12118092 0.82 ACLY (0.52) ACLYALDH1A1XDHRAB9A
SCHEMBL1316613 0.82 SCN10A (0.49) ACLYALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 ACLY 295/4885ABCB1 4395/4885MAPT 4045/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.