SCHEMBL1318129

SCHEMBL1318129

CC(C)Oc1ccccc1-c1ccc(C(=O)O)c(NC(=O)c2cncc(-c3ccccc3)c2)c1.[NaH]

nearest known ligand 0.49

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MKNK1 Q9BUB5 1/20 0.49
MKNK2 Q9HBH9 1/20 0.49
XDH P47989 4/20 0.48
ACLY P53396 3/20 0.46
ALDH1A1 P00352 1/20 0.43
SCN10A Q9Y5Y9 2/20 0.42
CAMKK2 Q96RR4 2/20 0.42
DHODH Q02127 1/20 0.41
ABL1 P00519 1/20 0.41
SUCNR1 Q9BXA5 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1318127 0.91 MKNK1 (0.48) MKNK1MKNK2XDHSCN10ACAMKK2
SCHEMBL15127674 0.90 ACLY (0.47) XDHACLYALDH1A1SCN10ADHODH
SCHEMBL1317879 0.88 ACLY (0.50) XDHACLYALDH1A1DHODH
SCHEMBL1316295 0.87 ALDH1A1 (0.47) XDHACLYALDH1A1CAMKK2DHODH
SCHEMBL2269612 0.86 HDAC1 (0.53) ACLYDHODHABL1
SCHEMBL1316613 0.85 SCN10A (0.49) ACLYALDH1A1SCN10ACAMKK2DHODH
SCHEMBL1316590 0.85 ACLY (0.50) XDHACLYALDH1A1SCN10ACAMKK2
SCHEMBL1317201 0.84 ACLY (0.51) XDHACLYALDH1A1SCN10ACAMKK2
SCHEMBL1317586 0.84 ACLY (0.51) XDHACLYALDH1A1
SCHEMBL13205939 0.83 ACLY (0.51) XDHACLYALDH1A1SCN10ACAMKK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8492582-B2 N-acyl anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2013-07-23 US disclosed
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2011-11-10 US disclosed
EP-2385036-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF Toyama Chemical Co., Ltd. (JP) 2011-11-09 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110275797-A1 N-ACYL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF COL14A1, COL2A1, COL1A1 MKNK1 3237/4885MKNK2 2960/4885XDH 14/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.