Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PYGL | P06737 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13190241 | 0.85 | PYGL (0.43) | POLBAPEX1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL3820327 | 0.80 | POLB (0.53) | POLBAPEX1HPGDALDH1A1ALOX15 | |
| SCHEMBL7929417 | 0.78 | ALDH1A1 (0.45) | POLBAPEX1HPGDALDH1A1ALOX15 | |
| SCHEMBL16181917 | 0.78 | EGFR (0.34) | POLBAPEX1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1180396 | 0.74 | ALDH1A1 (0.45) | POLBAPEX1HPGDALDH1A1ALOX15 | |
| SCHEMBL10421170 | 0.74 | GPR35 (0.36) | POLBAPEX1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL13190085 | 0.74 | RAB9A (0.74) | POLBHPGDALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL15385122 | 0.73 | POLB (0.43) | POLBAPEX1HPGDALDH1A1ALOX15 | |
| SCHEMBL13445696 | 0.73 | ALDH1A1 (0.41) | POLBAPEX1HPGDALDH1A1ALOX15 | |
| SCHEMBL101268 | 0.72 | TSHR (0.42) | POLBHPGDALDH1A1ALOX15SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2403852-B1 | 2-AMINOBENZIMIDAZOLE-5-CARBOXAMIDES AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM INT (DE) | 2014-10-29 | — | — | EP | disclosed |
| WO-2010100249-A1 | 3H-IMIDAZO [4, 5 -C] PYRIDINE- 6 -CARBOXAMIDES AS ANTI- INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-10 | — | — | WO | disclosed |