Sugi Predict

Sugi Predict / Compounds / SCHEMBL1319282

SCHEMBL1319282

SCHEMBL1319282

CC(=O)c1ccc(B(O)O)cc1F

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MAOB P27338 4/20 0.43
▸ MAOA P21397 1/20 0.41
▸ CES2 O00748 1/20 0.39
▸ CES1 P23141 1/20 0.39
▸ CA2 P00918 2/20 0.35
▸ LPL P06858 1/20 0.35
▸ LIPG Q9Y5X9 1/20 0.35
▸ CA1 P00915 1/20 0.35
▸ DGAT1 O75907 1/20 0.35
▸ ENPP2 Q13822 1/20 0.34
▸ ALDH1A1 P00352 1/20 0.34
▸ CYP3A4 P08684 1/20 0.34
▸ HPGD P15428 1/20 0.34
▸ MAPK1 P28482 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30963904 1.00 MAOB (0.43) MAOBMAOACES2CES1CA2
SCHEMBL4847318 0.85 CES2 (0.39) MAOBMAOACES2CES1CA2
SCHEMBL362047 0.82 CES2 (0.41) CES2CES1CA2CA1ALDH1A1
SCHEMBL29689051 0.82 CES2 (0.41) CES2CES1CA2CA1ALDH1A1
SCHEMBL3791204 0.82 CA2 (0.39) CA2LPLLIPGCA1ENPP2
SCHEMBL290252 0.81 DGAT1 (0.56) CES2CES1CA2CA1DGAT1
SCHEMBL29951442 0.81 DGAT1 (0.56) CES2CES1CA2CA1DGAT1
SCHEMBL13644473 0.81 ALDH1A1 (0.48) CES2CES1CA2CA1DGAT1
SCHEMBL875274 0.80 KMT2A (0.40) CES2CES1ALDH1A1
SCHEMBL21508521 0.80 HSP90AB1 (0.43) CES2CES1LPLLIPGALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240132431-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2024-04-25 — — US disclosed
EP-4279476-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-22 — — EP disclosed
EP-4279476-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-22 — — EP disclosed
EP-4276092-A1 COMPOUND LIBRARY CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-15 — — EP disclosed
EP-4276092-A1 COMPOUND LIBRARY CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2023-11-15 — — EP disclosed
WO-2022149617-A1 COMPOUND LIBRARY 中外製薬株式会社 2022-07-14 — — WO disclosed
US-20210340121-A1 SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2021-11-04 — — US disclosed
US-20210214412-A1 GLUCOSE-RESPONSIVE INSULIN THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY 2021-07-15 — — US disclosed
US-11008302-B2 Substituted pyridine and pyrimidines and their use as GluN2B receptor modulators JANSSEN PHARMACEUTICA NV (BE) 2021-05-18 — — US disclosed
EP-3774732-A2 SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS Janssen Pharmaceutica NV (BE) 2021-02-17 — — EP disclosed
US-7049304-B2 Aryl boronic acids for treating obesity GENZYME CORPORATION (US) 2006-05-23 — — US disclosed
US-7041280-B2 Aryl boronate functionalized polymers for treating obesity GENZYME CORPORATION (US) 2006-05-09 — — US disclosed
US-20050107336-A1 Aryl boronic acids for treating obesity HOLMES-FARLEY STEPHEN R (US) 2005-05-19 — — US disclosed
US-6858592-B2 Aryl boronic acids for treating obesity GENZYME CORPORATION (US) 2005-02-22 — — US disclosed
EP-1404686-A1 ARYL BORONATE FUNCTIONALIZED POLYMERS FOR TREATING OBESITY Geltex Pharmaceuticals, Inc. (US) 2004-04-07 — — EP disclosed
EP-1404685-A1 ARYL BORONIC ACIDS FOR TREATING OBESITY Geltex Pharmaceuticals, Inc. (US) 2004-04-07 — — EP disclosed
US-20030064963-A1 Aryl boronic acids for treating obesity GELTEX PHARMACEUTICALS, INC. 2003-04-03 — — US disclosed
US-20030059399-A1 Aryl boronate functionalized polymers for treating obesity GELTEX PHARMACEUTICALS, INC. 2003-03-27 — — US disclosed
WO-2003002570-A1 ARYL BORONIC ACIDS FOR TREATING OBESITY GENZYME CORPORATION (US) 2003-01-09 — — WO disclosed
WO-2003002571-A1 ARYL BORONATE FUNCTIONALIZED POLYMERS FOR TREATING OBESITY GENZYME CORPORATION (US) 2003-01-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030059399-A1 Aryl boronate functionalized polymers for treating obesity CEL, AHR, LIPE MAOB 48/4885MAOA 123/4885CES2 47/4885
US-20050107336-A1 Aryl boronic acids for treating obesity FFAR3, NR1H3, NR1H4 MAOB 1132/4885MAOA 1376/4885CES2 457/4885
US-20210214412-A1 GLUCOSE-RESPONSIVE INSULIN IAPP, GPR119, GLP1R MAOB 4711/4885MAOA 4803/4885CES2 2984/4885
US-20210340121-A1 SUBSTITUTED PYRIDINE AND PYRIMIDINES AND THEIR USE AS GLUN2B RECEPTOR MODULATORS GRIN2B, GRIN2A, GRIN3B MAOB 368/4885MAOA 1367/4885CES2 3495/4885
US-20030064963-A1 Aryl boronic acids for treating obesity FFAR3, FFAR1, NR1H3 MAOB 1497/4885MAOA 2271/4885CES2 413/4885
US-20240132431-A1 METHOD FOR ALKYLATING ACIDIC FUNCTIONAL GROUP MGMT, MCL1, FANCF MAOB 107/4885MAOA 285/4885CES2 160/4885
US-11008302-B2 Substituted pyridine and pyrimidines and their use as GluN2B receptor modulators GRIN2B, GRIN2A, GRIN3B MAOB 312/4885MAOA 1038/4885CES2 3448/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.