Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12296002 | 0.93 | MAPT (0.44) | MAPTATMKDM4EKMT2ASTAT3 | |
| SCHEMBL12295983 | 0.93 | MAPT (0.44) | MAPTATMKDM4EKMT2ASTAT3 | |
| SCHEMBL12296014 | 0.90 | MAPT (0.40) | MAPTATMKDM4EKMT2ASTAT3 | |
| SCHEMBL2632620 | 0.89 | CHRM5 (0.42) | MAPTATMKDM4EKMT2ACYP1A2 | |
| SCHEMBL16481554 | 0.89 | CYP1A2 (0.54) | KMT2ACYP19A1CYP1A2CYP3A4APP | |
| SCHEMBL2632438 | 0.89 | MET (0.38) | MAPTATMKDM4EKMT2ASTAT3 | |
| SCHEMBL12328264 | 0.88 | SIGMAR1 (0.46) | — | |
| SCHEMBL12327945 | 0.88 | HDAC1 (0.45) | KMT2AALDH1A1MEN1 | |
| SCHEMBL12296056 | 0.86 | BCHE (0.50) | KDM4EKMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL12296038 | 0.86 | KDM4E (0.52) | KDM4EKMT2ACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110105245-A | A kind of preparation method of Vernakalant intermediate 3,4- Dimethoxyphenethyl 2,2,2- tribromo-acetyl imines | 北京哈三联科技有限责任公司 | 2019-08-09 | — | — | CN | disclosed |
| CN-105294530-B | A kind of process for purification of Vernakalant hydrochloride | 北京哈三联科技有限责任公司 | 2018-01-23 | — | — | CN | disclosed |
| CN-104610121-B | A kind of preparation method of Vernakalant hydrochloride | 北京哈三联科技有限责任公司 | 2017-11-07 | — | — | CN | disclosed |
| US-9586899-B2 | Synthetic process for aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2017-03-07 | — | — | US | disclosed |
| US-9586899-B2 | Synthetic process for aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2017-03-07 | — | — | US | disclosed |
| CN-105294530-A | Purification method of vernakalant hydrochloride | MEDISANTECH CORP | 2016-02-03 | — | — | CN | disclosed |
| US-20150336887-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | CORREVIO CANADA CORP. (CA) | 2015-11-26 | — | — | US | disclosed |
| US-20150336887-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | CORREVIO CANADA CORP. (CA) | 2015-11-26 | — | — | US | disclosed |
| US-9115081-B2 | Synthetic process for aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2015-08-25 | — | — | US | disclosed |
| US-9115081-B2 | Synthetic process for aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2015-08-25 | — | — | US | disclosed |
| US-20080021005-A1 | Pegylated Ion Channel Modulating Compounds | CARDIOME PHARMA CORP. (CA) | 2008-01-24 | — | — | US | disclosed |
| US-20070254945-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2007-11-01 | — | — | US | disclosed |
| US-20070099983-A1 | Aminocyclohexyl ether compounds and uses thereof | CARDIOME PHARMA CORP. (CA) | 2007-05-03 | — | — | US | disclosed |
| US-20070088075-A1 | Deuterated aminocyclohexyl ether compounds and processes for preparing same | CARDIOME PHARMA CORP. (CA) | 2007-04-19 | — | — | US | disclosed |
| US-20070088075-A1 | Deuterated aminocyclohexyl ether compounds and processes for preparing same | CARDIOME PHARMA CORP. (CA) | 2007-04-19 | — | — | US | disclosed |
| US-20070015924-A1 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2007-01-18 | — | — | US | disclosed |
| US-20060094880-A9 | Synthetic process for trans-aminocyclohexyl ether compounds | BARRETT ANTHONY G M | 2006-05-04 | — | — | US | disclosed |
| WO-2005097087-A2 | MERGED ION CHANNEL MODULATING COMPOUNDS AND USES THEREOF | CARDIOME PHARMA CORP. (CA) | 2005-10-20 | — | — | WO | disclosed |
| WO-2005016242-A2 | SYNTHETIC PROCESS FOR TRANS-AMINOCYCLOHEXYL ETHER COMPOUNDS | CARDIOME PHARMA CORP. (CA) | 2005-02-24 | — | — | WO | disclosed |
| US-20050038256-A1 | Synthetic process for trans-aminocyclohexyl ether compounds | CARDIOME PHARMA CORP. (CA) | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094880-A9 | Synthetic process for trans-aminocyclohexyl ether compounds | AKR1C3, CBR1, CBR3 | MAPT 4883/4885ATM 2750/4885KDM4E 3727/4885 |
| US-20080021005-A1 | Pegylated Ion Channel Modulating Compounds | KCNN3, KCNN2, KCNN1 | MAPT 1655/4885ATM 4463/4885KDM4E 3982/4885 |
| US-20070088075-A1 | Deuterated aminocyclohexyl ether compounds and processes for preparing same | DDC, HDHD5, DDT | MAPT 3508/4885ATM 2258/4885KDM4E 265/4885 |
| US-20070254945-A1 | AMINOCYCLOHEXYL ETHER COMPOUNDS AND USES THEREOF | KCNH2, KCNC1, KCNH3 | MAPT 4479/4885ATM 3572/4885KDM4E 403/4885 |
| US-20050038256-A1 | Synthetic process for trans-aminocyclohexyl ether compounds | AKR1C3, CBR1, CBR3 | MAPT 4883/4885ATM 2750/4885KDM4E 3727/4885 |
| US-20150336887-A1 | SYNTHETIC PROCESS FOR AMINOCYCLOHEXYL ETHER COMPOUNDS | DDC, PAICS, CYP4F2 | MAPT 3088/4885ATM 1974/4885KDM4E 1008/4885 |
| US-20070015924-A1 | Synthetic processes for the preparation of aminocyclohexyl ether compounds | CYP2D6, CYP3A43, CYP2F1 | MAPT 3487/4885ATM 3961/4885KDM4E 963/4885 |
| US-20070099983-A1 | Aminocyclohexyl ether compounds and uses thereof | KCNH2, KCNC1, KCNH3 | MAPT 4479/4885ATM 3572/4885KDM4E 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.