Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylphenylsulfone SCHEMBL28390314 | 0.84 | ALDH1A1 (0.38) | PTGS2AKR1C3AKR1C2AKR1C1ALDH1A1 | |
| Methylphenylsulfone SCHEMBL28390752 | 0.84 | HSD11B1 (0.40) | PTGS2AKR1C3AKR1C2AKR1C1ALDH1A1 | |
| Methylphenylsulfone SCHEMBL28389024 | 0.78 | ALDH1A1 (0.41) | ALDH1A1GAA | |
| Methylphenylsulfone SCHEMBL13268396 | 0.78 | HPGD (0.44) | ALDH1A1GAAHSD17B10 | |
| Methylphenylsulfone SCHEMBL17498119 | 0.77 | KDM4E (0.50) | PTGS2ALDH1A1HSD17B10 | |
| Methylphenylsulfone SCHEMBL28888116 | 0.76 | MAPK1 (0.41) | PTGS2ALDH1A1GAAHSD17B10 | |
| Methylphenylsulfone SCHEMBL17498177 | 0.75 | KAT2B (0.40) | PTGS2AKR1C3 | |
| Methylphenylsulfone SCHEMBL1332357 | 0.73 | PTGS2 (0.62) | PTGS2ALDH1A1HSD17B10ENPP2 | |
| Methylphenylsulfone SCHEMBL78253 | 0.73 | PTGS2 (0.62) | PTGS2ALDH1A1HSD17B10ENPP2 | |
| Methylphenylsulfone SCHEMBL25293256 | 0.72 | PTGS2 (0.52) | PTGS2AKR1C3AKR1C2AKR1C1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180050985-A1 | N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES | THE JOHNS HOPKINS UNIVERSITY | 2018-02-22 | — | — | US | disclosed |
| US-20160046570-A1 | N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES | THE JOHNS HOPKINS UNIVERSITY | 2016-02-18 | — | — | US | disclosed |
| EP-2509941-A2 | N-ACYLATED HYDROXYLAMINE DERIVATIVES AND O-ACYLATED HYDROXYLAMINE DERIVATIVES | The Johns Hopkins University (US) | 2012-10-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180050985-A1 | N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES | TNNI3, TNNT2, NOS2 | PTGS2 45/4885AKR1C3 346/4885AKR1C2 211/4885 |
| US-20160046570-A1 | N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES | TNNI3, TNNT2, TNNC1 | PTGS2 57/4885AKR1C3 380/4885AKR1C2 227/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.