Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TDP2 | O95551 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAT2A | P31153 | 2/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.32 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | CDC7 | O00311 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17907965 | 0.77 | HTR2A (0.48) | TDP2NOTUMKMT2AMAT2A | |
| SCHEMBL17907930 | 0.68 | HTR2A (0.48) | ALDH1A1NOTUMKMT2ACCR2 | |
| SCHEMBL17907932 | 0.68 | SIGMAR1 (0.41) | ALDH1A1NOTUML3MBTL1 | |
| SCHEMBL17907920 | 0.65 | HTR2A (0.51) | ALDH1A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL9491661 | 0.63 | TDP2 (0.50) | TDP2NOTUMPARP1PARP10SRD5A1 | |
| SCHEMBL4043789 | 0.62 | HTR2A (0.42) | ALDH1A1TDP2CYP11B2KIF11HTR7 | |
| SCHEMBL4043791 | 0.62 | HTR2A (0.42) | ALDH1A1TDP2CYP11B2KIF11HTR7 | |
| SCHEMBL31743109 | 0.62 | BRPF1 (0.52) | ALDH1A1MAT2ATRPV1KIF11HTR7 | |
| SCHEMBL1770250 | 0.61 | NOTUM (0.35) | NOTUMTSHR | |
| SCHEMBL27989957 | 0.61 | ALDH1A1 (0.58) | ALDH1A1NOTUMMEN1KMT2AALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |