Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MAT2A | P31153 | 1/20 | 0.30 |
| ▸ | AHR | P35869 | 1/20 | 0.30 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13279280 | 0.87 | SIGMAR1 (0.42) | NOTUMSIGMAR1DAOHTR2AHTR2C | |
| SCHEMBL17907965 | 0.81 | HTR2A (0.48) | NOTUMDAOHTR2AHTR2CMAT2A | |
| SCHEMBL17907947 | 0.80 | ALDH1A1 (0.38) | NOTUMATMMAT2ASRD5A1 | |
| SCHEMBL235219 | 0.78 | NOTUM (0.59) | NOTUMSIGMAR1HTR2AHTR2C | |
| SCHEMBL9844700 | 0.77 | NOTUM (0.62) | NOTUMDAOHTR2AHTR2CATM | |
| SCHEMBL19921245 | 0.75 | HTR2A (0.39) | SIGMAR1HTR2AHTR2CAHR | |
| SCHEMBL17907932 | 0.71 | SIGMAR1 (0.41) | NOTUMSIGMAR1HTR2AHTR2C | |
| SCHEMBL17907930 | 0.71 | HTR2A (0.48) | NOTUMHTR2AHTR2C | |
| SCHEMBL26837141 | 0.70 | HTR2A (0.65) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL17907920 | 0.68 | HTR2A (0.51) | HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2697223-B1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2016-07-13 | — | — | EP | disclosed |
| EP-2697223-A1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | Actelion Pharmaceuticals Ltd. (CH) | 2014-02-19 | — | — | EP | disclosed |
| WO-2012140612-A1 | 7-(HETEROARYL-AMINO)-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-10-18 | — | — | WO | disclosed |