Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27029417 | 0.85 | MAPT (0.48) | MAPTKMT2AHSD17B10TSHRIKBKB | |
| SCHEMBL21612060 | 0.82 | KMT2A (0.54) | MAPTKMT2AHSD17B10TSHRPTPN1 | |
| SCHEMBL21858572 | 0.81 | HSD17B10 (0.46) | MAPTKMT2AHSD17B10TSHRIKBKB | |
| SCHEMBL20598163 | 0.80 | MAPT (0.42) | MAPTKMT2AHSD17B10TSHRALDH1A1 | |
| SCHEMBL1973056 | 0.78 | MAPT (0.50) | MAPTKMT2AHSD17B10TSHRGPR35 | |
| SCHEMBL1529858 | 0.78 | MAPT (0.50) | MAPTKMT2AHSD17B10TSHRPTPN1 | |
| SCHEMBL2682770 | 0.77 | MAPT (0.48) | MAPTKMT2AHSD17B10TSHRPTPN1 | |
| SCHEMBL15537262 | 0.77 | KMT2A (0.48) | MAPTKMT2AHSD17B10TSHRPTPN1 | |
| SCHEMBL23531546 | 0.77 | KMT2A (0.44) | MAPTKMT2AHSD17B10TSHRIKBKB | |
| SCHEMBL16065014 | 0.75 | GPR35 (0.48) | TSHRPTPN1GPR35 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11884643-B2 | Substituted thiophenecarboxamides and analogues as antibacterials agents | BAYER AKTIENGESELLSCHAFT (DE) | 2024-01-30 | — | — | US | claimed |
| EP-3818050-B1 | SUBSTITUTED THIOPHENECARBOXAMIDES AND ANALOGUES AS ANTIBACTERIALS AGENTS | BAYER AG (DE) | 2023-05-31 | — | — | EP | claimed |
| US-20230159506-A1 | SUBSTITUTED THIOPHENECARBOXAMIDES AND ANALOGUES AS ANTIBACTERIALS AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-05-25 | — | — | US | claimed |
| EP-3818050-A1 | SUBSTITUTED THIOPHENECARBOXAMIDES AND ANALOGUES AS ANTIBACTERIALS AGENTS | Bayer Aktiengesellschaft (DE) | 2021-05-12 | — | — | EP | claimed |
| CN-112638893-A | Substituted thiophenecarboxamides and analogs as antibacterial agents | 拜耳公司 | 2021-04-09 | — | — | CN | claimed |
| WO-2020007905-A1 | SUBSTITUTED THIOPHENECARBOXAMIDES AND ANALOGUES AS ANTIBACTERIALS AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-01-09 | — | — | WO | claimed |
| EP-3994130-B1 | SUBSTITUTED THIOPHENE CARBOXAMIDES AND DERIVATIVES THEREOF AS MICROBICIDES | BAYER AG (DE) | 2024-07-10 | — | — | EP | disclosed |
| CN-114364663-B | Substituted thiophenecarboxamides and derivatives thereof as microbiocides | 拜耳公司 | 2024-07-05 | — | — | CN | disclosed |
| CN-112638893-B | Substituted thiophenecarboxamides and analogues as antibacterial agents | 拜耳公司 | 2024-03-29 | — | — | CN | disclosed |
| US-11884643-B2 | Substituted thiophenecarboxamides and analogues as antibacterials agents | BAYER AKTIENGESELLSCHAFT (DE) | 2024-01-30 | — | — | US | disclosed |
| EP-3818050-B1 | SUBSTITUTED THIOPHENECARBOXAMIDES AND ANALOGUES AS ANTIBACTERIALS AGENTS | BAYER AG (DE) | 2023-05-31 | — | — | EP | disclosed |
| US-20230159506-A1 | SUBSTITUTED THIOPHENECARBOXAMIDES AND ANALOGUES AS ANTIBACTERIALS AGENTS | BAYER AKTIENGESELLSCHAFT (DE) | 2023-05-25 | — | — | US | disclosed |
| CN-115667237-A | Novel heterocyclic compounds as BET inhibitors | 成都苑东生物制药股份有限公司 | 2023-01-31 | — | — | CN | disclosed |
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| US-20080027048-A1 | Such as 5-(3-cyano-4-n-propoxyphenyl)thiophene-2-carboxylic acid; for diseases associated with xanthine oxidase such as hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy | ASTELLAS PHARMA INC. (JP) | 2008-01-31 | — | — | US | disclosed |
| US-20070270458-A1 | Nicotinic Acetylcholine Receptor Ligands | ASTRAZENECA AB (SE) | 2007-11-22 | — | — | US | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |
| EP-1783124-A1 | 2-PHENYLTHIOPHENE DERIVATIVE | Astellas Pharma Inc. (JP) | 2007-05-09 | — | — | EP | disclosed |
| EP-1699786-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| WO-2005061494-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11884643-B2 | Substituted thiophenecarboxamides and analogues as antibacterials agents | XDH, TST, BLVRB | MAPT 4393/4885KMT2A 4407/4885HSD17B10 1993/4885 |
| US-20230159506-A1 | SUBSTITUTED THIOPHENECARBOXAMIDES AND ANALOGUES AS ANTIBACTERIALS AGENTS | XDH, TST, BLVRB | MAPT 4393/4885KMT2A 4407/4885HSD17B10 1993/4885 |
| US-20070270458-A1 | Nicotinic Acetylcholine Receptor Ligands | CHRNA2, CHRNA1, CHRNA6 | MAPT 1079/4885KMT2A 1225/4885HSD17B10 2709/4885 |
| US-20080027048-A1 | Such as 5-(3-cyano-4-n-propoxyphenyl)thiophene-2-carboxylic acid; for diseases associated with xanthine oxidase such as hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy | XDH, UACA, NUDT1 | MAPT 1064/4885KMT2A 3232/4885HSD17B10 699/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.