Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | BRD4 | O60885 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.43 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.42 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.42 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.42 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13302814 | 0.84 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL13425478 | 0.83 | MEN1 (0.55) | MEN1KMT2AALDH1A1MAPTMAPK10 | |
| SCHEMBL7095756 | 0.78 | ABCC9 (0.58) | ALDH1A1MAPTKDM4EBRD4HTT | |
| SCHEMBL29044382 | 0.74 | MAPT (0.73) | MEN1KMT2AALDH1A1MAPTMAPK10 | |
| SCHEMBL15976552 | 0.73 | ALDH1A1 (0.74) | MEN1KMT2AALDH1A1MAPTMAPK10 | |
| SCHEMBL13302828 | 0.73 | KMT2A (0.50) | MEN1KMT2AALDH1A1MAPTKDM4E | |
| SCHEMBL395878 | 0.71 | TDP1 (0.66) | KMT2AALDH1A1MAPTMAPK10KDM4E | |
| SCHEMBL19955179 | 0.71 | TDP1 (0.66) | KMT2AALDH1A1MAPTMAPK10KDM4E | |
| SCHEMBL31738422 | 0.71 | TDP1 (0.66) | KMT2AALDH1A1MAPTMAPK10KDM4E | |
| SCHEMBL16424678 | 0.71 | BRD4 (0.61) | MEN1KMT2AALDH1A1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100152206-A1 | Bicyclic Dihydropyrimidines and Uses Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152206-A1 | Bicyclic Dihydropyrimidines and Uses Thereof | KIF5A, KIF5C, KIF5B | MEN1 2916/4885KMT2A 1008/4885ALDH1A1 739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.