Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BBOX1 | O75936 | 2/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11769924 | 0.96 | GMNN (0.38) | BBOX1GMNNALDH1A1LMNATP53 | |
| Lithium Ion SCHEMBL1303199 | 0.85 | KDM4E (0.33) | BBOX1 | |
| SCHEMBL1303309 | 0.85 | KDM4E (0.38) | BBOX1GMNNALDH1A1LMNATP53 | |
| SCHEMBL973803 | 0.81 | APP (0.37) | LMNACES2 | |
| SCHEMBL4056939 | 0.80 | BBOX1 (0.53) | BBOX1LMNA | |
| SCHEMBL6259281 | 0.79 | CES2 (0.33) | CES2 | |
| Potassium Ion SCHEMBL31075019 | 0.77 | GMNN (0.46) | BBOX1GMNNALDH1A1LMNATP53 | |
| SCHEMBL7770974 | 0.76 | CES2 (0.37) | CES2 | |
| SCHEMBL7256155 | 0.75 | CES2 (0.39) | TSHRCES2 | |
| SCHEMBL871697 | 0.75 | CES2 (0.44) | TSHRCES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8753686-B2 | Surface-treating agents, surface-treated powders, and cosmetics comprising the same | SHISEIDO CO., LTD. (JP) | 2014-06-17 | — | — | US | disclosed |
| US-20110280946-A1 | Surface-Treating Agents, Surface-Treated Powders, And Cosmetics Comprising The Same | SHISEIDO CO., LTD. (JP) | 2011-11-17 | — | — | US | disclosed |
| EP-2112179-B1 | Surface-treated powders, and cosmetics comprising the same | SHISEIDO CO LTD (JP) | 2011-04-27 | — | — | EP | disclosed |
| EP-1803750-B1 | USE OF A POLYMER FOR SURFACE-TREATING A POWDER | SHISEIDO CO LTD (JP) | 2009-12-09 | — | — | EP | disclosed |
| EP-2112179-A1 | Surface-treated powders, and cosmetics comprising the same | Shiseido Co., Ltd. (JP) | 2009-10-28 | — | — | EP | disclosed |
| US-20080081029-A1 | acrylic homopolymers or copolymers, that can provide excellent hydrophobicity to powders or cosmetics, and can improve its rinsability | SHISEIDO CO., LTD. (JP) | 2008-04-03 | — | — | US | disclosed |
| EP-1803750-A1 | SURFACE-TREATING AGENT, SURFACE-TREATED POWDER, AND COSMETIC PREPARATION CONTAINING SAME | Shiseido Company, Limited (JP) | 2007-07-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081029-A1 | acrylic homopolymers or copolymers, that can provide excellent hydrophobicity to powders or cosmetics, and can improve its rinsability | CHRM1, H1-0, H1-2 | BBOX1 2452/4885GMNN 2440/4885ALDH1A1 142/4885 |
| US-20110280946-A1 | Surface-Treating Agents, Surface-Treated Powders, And Cosmetics Comprising The Same | CHRM1, H1-0, H1-2 | BBOX1 2055/4885GMNN 2944/4885ALDH1A1 115/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.