Known targets — ChEMBL curated mechanism
ABCC8ACEADORA1ADORA2AADORA2BADORA3ALDH5A1ALOX5ALOX5APATP4AATP4BBRAFCA1CA12CA2CA4CYSLTR1DHFRDPEP1EDNRAEDNRBESR2F10FDPSFGF1GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTGNRHRGSC1HMGCRIMPDH1IMPDH2KCNJ11LY96NOD2NR3C1NS3NS4ANS5bP2RY1P2RY12P2RY2P2RY4P2RY6PBP2XPDE3APDE3BPDE4APDE4BPDE4CPDE4DPDK1PDK2PDK3PDK4PPARGPPATPTGIRPTGS1PTGS2RAF1RYR1RYR3SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASERPINC1SLC12A1SLC12A3SYKTHRATHRBTLR3TLR4TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYMSVKORC1XDHblablaIMP-1blaOXA-33blaOXA-58blaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAfolPfolP1ftsIfusAgaggyrAgyrBmecAmrcAmrcBmrdApbp1apbp1bpbp2pbp2apbp2bpbp3pbp4pbpApbpBpbpCpbpFpolponBrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpoArpoBrpoCrpoZrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methyl Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 known ✓ | P00918 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.56 |
| ▸ | FAAH | O00519 | 4/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | HBB | P68871 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | BBOX1 | O75936 | 2/20 | 0.43 |
| ▸ | CES1 | P23141 | 6/20 | 0.42 |
| ▸ | CES2 | O00748 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL10778854 | 1.00 | EPHX2 (0.56) | EPHX2FAAHRECQLTSHRMAPK1 | |
| Methyl Alcohol SCHEMBL27780506 | 1.00 | EPHX2 (0.56) | EPHX2FAAHRECQLTSHRMAPK1 | |
| Methyl Alcohol SCHEMBL25250336 | 1.00 | EPHX2 (0.56) | EPHX2FAAHRECQLTSHRMAPK1 | |
| Methyl Alcohol SCHEMBL284907 | 1.00 | EPHX2 (0.56) | EPHX2FAAHRECQLTSHRMAPK1 | |
| SCHEMBL22390665 | 0.95 | EPHX2 (0.54) | EPHX2FAAHRECQLTSHRMAPK1 | |
| SCHEMBL22390768 | 0.95 | EPHX2 (0.54) | EPHX2FAAHRECQLTSHRMAPK1 | |
| SCHEMBL22390657 | 0.95 | EPHX2 (0.54) | EPHX2FAAHRECQLTSHRMAPK1 | |
| SCHEMBL22390628 | 0.95 | EPHX2 (0.54) | EPHX2FAAHRECQLTSHRMAPK1 | |
| SCHEMBL22390671 | 0.95 | EPHX2 (0.54) | EPHX2FAAHRECQLTSHRMAPK1 | |
| SCHEMBL22390625 | 0.95 | EPHX2 (0.54) | EPHX2FAAHRECQLTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11692022-B2 | Thiosuccinyl-crosslinked hemoglobin analogs and methods of use and preparation thereof | BILLION KING INTERNATIONAL LIMITED (CN) | 2023-07-04 | — | — | US | disclosed |
| US-20230111100-A1 | Thiosuccinyl-crosslinked Hemoglobin Analogs and Methods of Use and Preparation Thereof | BILLION KING INTERNATIONAL LIMITED (HK) | 2023-04-13 | — | — | US | disclosed |
| US-20210061885-A1 | Thiosuccinyl-crosslinked Hemoglobin Analogs and Methods of Use and Preparation Thereof | BILLION KING INTERNATIONAL LIMITED (CN) | 2021-03-04 | — | — | US | disclosed |
| US-20120058511-A1 | MUTANT MICROORGANISM AND METHOD FOR PRODUCING PEPTIDE USING THE SAME | AJINOMOTO CO., INC., (JP) | 2012-03-08 | — | — | US | disclosed |
| US-20050176150-A1 | Mutant microorganism and method for producing peptide using the same | AJINOMOTO CO., INC. (JP) | 2005-08-11 | — | — | US | disclosed |
| EP-1561810-A2 | Mutant microorganism and method for producing peptide using the same | Ajinomoto Co., Inc. (JP) | 2005-08-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210061885-A1 | Thiosuccinyl-crosslinked Hemoglobin Analogs and Methods of Use and Preparation Thereof | HBG1, HBG2, HBB | CA2 3321/4885EPHX2 889/4885FAAH 3547/4885 |
| US-11692022-B2 | Thiosuccinyl-crosslinked hemoglobin analogs and methods of use and preparation thereof | HBG1, HBG2, HBB | CA2 3321/4885EPHX2 889/4885FAAH 3547/4885 |
| US-20230111100-A1 | Thiosuccinyl-crosslinked Hemoglobin Analogs and Methods of Use and Preparation Thereof | HBG1, HBG2, HBB | CA2 3321/4885EPHX2 889/4885FAAH 3547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.