Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.44 |
| ▸ | PGR | P06401 | 4/20 | 0.44 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13359831 | 0.84 | HTR1B (0.50) | SLC6A4NR3C1PGRNR3C2ALOX15 | |
| Water SCHEMBL1530715 | 0.83 | NR3C1 (0.45) | SLC6A4NR3C1PGRNR3C2ALOX15 | |
| SCHEMBL13228076 | 0.78 | ALOX15 (0.48) | NR3C1PGRNR3C2ALOX15ALOX12 | |
| SCHEMBL12405916 | 0.77 | ALOX15 (0.61) | NR3C1PGRALOX15ALOX12MEN1 | |
| SCHEMBL3960259 | 0.76 | GABRA1 (0.60) | NR3C1PGRALOX15ALOX12MEN1 | |
| SCHEMBL29770953 | 0.73 | SLC6A4 (0.47) | SLC6A4NR3C1PGRALOX15ALOX12 | |
| SCHEMBL5147833 | 0.73 | SLC6A4 (0.47) | SLC6A4NR3C1PGRALOX15ALOX12 | |
| SCHEMBL892653 | 0.73 | TAAR1 (0.57) | NR3C1PGRALOX15ALOX12MEN1 | |
| Hydrochloric Acid SCHEMBL1530712 | 0.72 | SLC6A4 (0.46) | SLC6A4NR3C1PGRALOX15ALOX12 | |
| SCHEMBL24505612 | 0.71 | ALOX15 (0.63) | NR3C1PGRALOX15ALOX12MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090325962-A1 | TYROSINE DERIVATIVE | GENENTECH, INC. (US) | 2009-12-31 | — | — | US | disclosed |
| US-7595399-B2 | Tyrosine derivatives | GENENTECH, INC. (US) | 2009-09-29 | — | — | US | disclosed |
| US-20080075719-A1 | Method for Augmenting B Cell Depletion | GENENTECH, INC. (US) | 2008-03-27 | — | — | US | disclosed |
| US-20080075719-A1 | Method for Augmenting B Cell Depletion | GENENTECH, INC. (US) | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090325962-A1 | TYROSINE DERIVATIVE | VCAM1, ICAM1, ITGB4 | SLC6A4 340/4885NR3C1 2638/4885PGR 4009/4885 |
| US-20080075719-A1 | Method for Augmenting B Cell Depletion | CD22, ITGAM, FCGR3B | SLC6A4 4255/4885NR3C1 1185/4885PGR 2834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.