Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2094076 | 0.75 | CYP1A2 (0.38) | LMNAGAAMAPTGFERPTK2B | |
| SCHEMBL3168133 | 0.73 | ALDH1A1 (0.43) | LMNAMAPTSMN1; SMN2CYP1A2TSHR | |
| SCHEMBL10512435 | 0.70 | KMT2A (0.35) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL11187663 | 0.70 | CYP1A2 (0.39) | LMNAGAAMAPTGFERPTK2B | |
| SCHEMBL1686581 | 0.69 | ADRA2A (0.52) | LMNAGAACYP1A2CYP2A6TSHR | |
| SCHEMBL16119585 | 0.67 | SRC (0.43) | LMNAGAAMAPTGFERPTK2B | |
| SCHEMBL1361442 | 0.67 | TAAR1 (0.41) | GAAMAPTSMN1; SMN2TDP1CYP1A2 | |
| SCHEMBL2295342 | 0.65 | KMT2A (0.53) | LMNAGAAMAPTSMN1; SMN2TDP1 | |
| SCHEMBL9511244 | 0.65 | CYP1A2 (0.43) | LMNAGAATDP1CYP1A2CYP2A6 | |
| SCHEMBL22489476 | 0.65 | CYP1A2 (0.43) | LMNAGAATDP1CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008150-B1 | 2,6-DICHLOROPHENYL-SUBSTITUTED AMINO-IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARING SUCH DERIVATIVES AND PHARMACEUTICAL PREPARATIONS COMPRISING SAID DERIVATIVES | Farmos-Yhtyma Oy (FI) | 1982-04-28 | — | — | EP | claimed |
| EP-0008150-A2 | 2,6-Dichlorophenyl-substituted amino-imidazole derivatives, processes of preparing such derivatives and pharmaceutical preparations comprising said derivatives | Farmos-Yhtyma Oy (FI) | 1980-02-20 | — | — | EP | claimed |
| US-9765020-B2 | Dichlorophenyl-imino compounds and compositions, and methods for the treatment of mucositis | CELLIX BIO PRIVATE LIMITED (IN) | 2017-09-19 | — | — | US | disclosed |
| US-9765020-B2 | Dichlorophenyl-imino compounds and compositions, and methods for the treatment of mucositis | CELLIX BIO PRIVATE LIMITED (IN) | 2017-09-19 | — | — | US | disclosed |
| US-20150307446-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUCOSITIS | CELLIX BIO PRIVATE LIMITED (IN) | 2015-10-29 | — | — | US | disclosed |
| US-20150307446-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUCOSITIS | CELLIX BIO PRIVATE LIMITED (IN) | 2015-10-29 | — | — | US | disclosed |
| WO-2013175377-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUCOSITIS | KANDULA MAHESH (IN) | 2013-11-28 | — | — | WO | disclosed |
| US-8067614-B2 | N-substituted (benzoimidazol-2-yl)phenylamines, processes for their preparation, their use as a medicament or diagnostic aid, and a medicament comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2011-11-29 | — | — | US | disclosed |
| US-20100168196-A1 | N-Substituted (Benzoimidazol-2-yl)phenylamines, Processes for Their Preparation, Their Use as a Medicament or Diagnostic Aid, and a Medicament Comprising Them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-07-01 | — | — | US | disclosed |
| EP-1857445-B1 | Substituted 2 amino imidazoles, method for their manufacture and their use as a drug or diagnostic and drug containing them | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-15 | — | — | EP | disclosed |
| US-20080275098-A1 | Inhibit sodium proton exchangers; central nervous system, respiratory system, cardiovascular, urogenital, pyschological, biliary function and kidney disorders; sleep apnea, strokes; ketalization, acetalization, cyclization; similar to clonidine; hypotensive, antidiabetic, and antiischemic agents | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-11-06 | — | — | US | disclosed |
| WO-2004069811-A1 | N-SUBSTITUTED (BENZOIMIDAZOLE-2-YL) PHENYL AMINES, METHOD FOR THEIR PRODUCTION, THEIR USE AS A MEDICAMENT OR DIAGNOSTIC AGENT AND MEDICAMENT CONTAINING SAID SUBSTANCES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-19 | — | — | WO | disclosed |
| WO-2004069806-A2 | SUBSTITUTED 2-AMINOIMIDAZOLES, METHOD FOR THE PRODUCTION THEREOF, THEIR USE AS A MEDICAMENT OR AS A DIAGNOSTIC REAGENT, AND MEDICAMENT CONTAINING THESE COMPOUNDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-08-19 | — | — | WO | disclosed |
| EP-0008150-B1 | 2,6-DICHLOROPHENYL-SUBSTITUTED AMINO-IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARING SUCH DERIVATIVES AND PHARMACEUTICAL PREPARATIONS COMPRISING SAID DERIVATIVES | Farmos-Yhtyma Oy (FI) | 1982-04-28 | — | — | EP | disclosed |
| US-4290971-A | HYPOTENSIVE AGENTS | DSO "PHARMACHIM" (BG) | 1981-09-22 | — | — | US | disclosed |
| US-4275072-A | 2,6-Dichlorophenyl-substituted amino-imidazole derivatives and use as hypertensive agents | FARMOS GROUP, LTD. (FI) | 1981-06-23 | — | — | US | disclosed |
| EP-0008150-A2 | 2,6-Dichlorophenyl-substituted amino-imidazole derivatives, processes of preparing such derivatives and pharmaceutical preparations comprising said derivatives | Farmos-Yhtyma Oy (FI) | 1980-02-20 | — | — | EP | disclosed |
| US-4146647-A | PHENYLAMIDOXIMES, HYPOTENSIVE AGENTS | LABORATOIRE L. LAFON (FR) | 1979-03-27 | — | — | US | disclosed |
| US-4101675-A | ANTIHYPERTENSIVES | AKZONA INCORPORATED (US) | 1978-07-18 | — | — | US | disclosed |
| US-3972932-A | Novel 2,6-disubstituted phenyl-aminoguanidine compounds | AKZONA INCORPORATED (US) | 1976-08-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275098-A1 | Inhibit sodium proton exchangers; central nervous system, respiratory system, cardiovascular, urogenital, pyschological, biliary function and kidney disorders; sleep apnea, strokes; ketalization, acetalization, cyclization; similar to clonidine; hypotensive, antidiabetic, and antiischemic agents | ATP6V1B1, SLC10A1, GLS | LMNA 2655/4885GAA 576/4885MAPT 4163/4885 |
| US-20100168196-A1 | N-Substituted (Benzoimidazol-2-yl)phenylamines, Processes for Their Preparation, Their Use as a Medicament or Diagnostic Aid, and a Medicament Comprising Them | SLC10A1, SLC9A3, ABCB11 | LMNA 751/4885GAA 905/4885MAPT 4360/4885 |
| US-20150307446-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF MUCOSITIS | MUC1, SI, ALPI | LMNA 3373/4885GAA 2308/4885MAPT 2326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.