Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 3/20 | 0.66 |
| ▸ | HRH1 | P35367 | 3/20 | 0.65 |
| ▸ | DRD2 | P14416 | 2/20 | 0.63 |
| ▸ | DRD4 | P21917 | 2/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6071440 | 0.98 | HTR1B (0.64) | HTR1BHRH1DRD2DRD4SLC6A4 | |
| SCHEMBL6318521 | 0.94 | HTR1B (0.73) | HTR1BHRH1DRD2DRD4SLC6A4 | |
| SCHEMBL10993201 | 0.90 | HTR1B (0.58) | HTR1BHRH1DRD2DRD4SLC6A4 | |
| SCHEMBL10984635 | 0.84 | CYP1A2 (0.59) | HTR1BHRH1DRD2DRD4SLC6A4 | |
| SCHEMBL23067912 | 0.84 | DRD2 (0.77) | HTR1BDRD2DRD4DRD3CYP1A2 | |
| SCHEMBL9808080 | 0.83 | ALDH1A1 (0.62) | DRD2DRD4DRD3CYP1A2L3MBTL1 | |
| SCHEMBL11679951 | 0.83 | CYP2D6 (0.61) | DRD2DRD4DRD3CYP1A2L3MBTL1 | |
| SCHEMBL18773934 | 0.81 | DRD2 (0.69) | HTR1BDRD2DRD4DRD3CYP1A2 | |
| SCHEMBL7908960 | 0.81 | HTR1B (0.69) | HTR1BHRH1SLC6A4CYP1A2CYP3A4 | |
| SCHEMBL1592876 | 0.81 | TDP1 (0.60) | DRD2DRD4DRD3CYP1A2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7619005-B2 | Methods for treating cognitive impairment in humans with Multiple Sclerosis | COGNITION PHARMACEUTICALS LLC (US) | 2009-11-17 | — | — | US | disclosed |
| US-20070197663-A1 | Methods of treating memory and cognitive impairments in humans following stroke and traumatic brain injury | EPSTEIN MEL H | 2007-08-23 | — | — | US | disclosed |
| US-20070117869-A1 | Methods for treating coginitive impairment and improving cognition | COGNITION PHARMACEUTICALS LLC | 2007-05-24 | — | — | US | disclosed |
| US-20070099999-A1 | Methods of treating depression | EPSTEIN MEL H | 2007-05-03 | — | — | US | disclosed |
| WO-2007000550-A2 | NOVEL INDOLINE COMPOUNDS | LABORATOIRES FOURNIER S.A. (FR) | 2007-01-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099999-A1 | Methods of treating depression | HTR1A, HTR1D, PNMT | HTR1B 8/4885HRH1 4173/4885DRD2 56/4885 |
| US-20070197663-A1 | Methods of treating memory and cognitive impairments in humans following stroke and traumatic brain injury | PNMT, COMT, MAP2 | HTR1B 76/4885HRH1 4662/4885DRD2 188/4885 |
| US-20070117869-A1 | Methods for treating coginitive impairment and improving cognition | COMT, PNMT, CHAT | HTR1B 18/4885HRH1 4614/4885DRD2 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.