Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 6/20 | 0.69 |
| ▸ | CSF1R | P07333 | 1/20 | 0.62 |
| ▸ | FLT1 | P17948 | 1/20 | 0.62 |
| ▸ | FLT3 | P36888 | 1/20 | 0.62 |
| ▸ | CNR1 | P21554 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.50 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
| ▸ | FNTA | P49354 | 1/20 | 0.48 |
| ▸ | FNTB | P49356 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | PEPD | P12955 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680547 | 0.88 | CNR1 (0.61) | KIF11CSF1RFLT1FLT3CNR1 | |
| SCHEMBL8265472 | 0.85 | HSD17B10 (0.66) | CSF1RFLT1FLT3CNR1KMT2A | |
| SCHEMBL27524136 | 0.84 | KIF11 (0.76) | KIF11KMT2AGAAMAPTGFER | |
| SCHEMBL13749770 | 0.83 | KIF11 (0.69) | KIF11CSF1RFLT1FLT3CNR1 | |
| SCHEMBL13680643 | 0.83 | CYP1A2 (0.67) | KIF11CSF1RFLT1FLT3CNR1 | |
| SCHEMBL5428805 | 0.82 | KIF11 (1.00) | KIF11GAAMAPTGFERPEPD | |
| SCHEMBL13680466 | 0.82 | FAAH (0.56) | CSF1RFLT1FLT3CNR1KMT2A | |
| SCHEMBL13680444 | 0.82 | CNR1 (0.62) | CSF1RFLT1FLT3CNR1KMT2A | |
| SCHEMBL13680447 | 0.81 | PNPLA2 (0.62) | CSF1RFLT1FLT3CNR1KMT2A | |
| SCHEMBL166848 | 0.80 | HSD17B10 (0.69) | KMT2AGAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |