Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KIF11 | P52732 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TYR | P14679 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680488 | 0.83 | KIF11 (0.59) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL13680461 | 0.78 | SMN1; SMN2 (0.60) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL13680701 | 0.77 | TOP2A (0.53) | ALDH1A1MAPTHPGDKDM4ENPC1 | |
| SCHEMBL1617568 | 0.76 | CA12 (0.50) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL13680510 | 0.75 | ALDH1A1 (0.52) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL13680486 | 0.75 | MAPT (0.52) | ALDH1A1POLBMAPTKMT2AMEN1 | |
| SCHEMBL23197679 | 0.75 | TDP1 (0.56) | ALDH1A1MAPTKMT2AMEN1GAA | |
| SCHEMBL14699695 | 0.74 | APP (0.44) | ALDH1A1MAPTKMT2AMEN1GAA | |
| SCHEMBL13680492 | 0.74 | TSHR (0.51) | ALDH1A1MAPTKMT2AMEN1GAA | |
| SCHEMBL13681315 | 0.73 | TOP2A (0.44) | ALDH1A1POLBMAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |