Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680840 | 0.85 | RAB9A (0.41) | NPC1ALDH1A1RAB9ASMN1; SMN2NFKB1 | |
| SCHEMBL13680834 | 0.84 | PDE10A (0.39) | PDE10AALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13680817 | 0.82 | ALDH1A1 (0.47) | PDE10ANPC1ALDH1A1RAB9AKDM4E | |
| SCHEMBL13680824 | 0.82 | SUCNR1 (0.44) | NPC1ALDH1A1RAB9AKDM4EADORA3 | |
| SCHEMBL13680849 | 0.82 | SCN9A (0.43) | FYNMAPTPIK3CASCN9A | |
| SCHEMBL3854280 | 0.82 | MEN1 (0.50) | PDE10AALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL13680828 | 0.81 | ALDH1A1 (0.42) | NPC1ALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13680838 | 0.81 | SCN9A (0.42) | NPC1RAB9ASMN1; SMN2NFKB1NFKB2 | |
| SCHEMBL13680842 | 0.81 | RAB9A (0.45) | NPC1ALDH1A1RAB9AKDM4ESMN1; SMN2 | |
| SCHEMBL13680839 | 0.81 | ALDH1A1 (0.45) | NPC1ALDH1A1RAB9AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |