Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680825 | 0.87 | MAPT (0.41) | ALDH1A1MAPTSMN1; SMN2HPGDLMNA | |
| SCHEMBL13680836 | 0.85 | NPC1 (0.44) | MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL13680851 | 0.84 | MAPK1 (0.43) | HPGD | |
| SCHEMBL13680830 | 0.84 | RARA (0.44) | ALDH1A1LOXL2KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL13680835 | 0.83 | MAP4K4 (0.42) | TLR8NPC1RAB9AERN1 | |
| SCHEMBL13680844 | 0.82 | SMN1; SMN2 (0.43) | ALDH1A1MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL13680837 | 0.82 | ALDH1A1 (0.40) | ALDH1A1KDM4EHPGDHSD17B10ERN1 | |
| SCHEMBL13680815 | 0.81 | PDE10A (0.46) | ALDH1A1MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL13680827 | 0.81 | KMT2A (0.50) | ALDH1A1MAPTKDM4ESMN1; SMN2NPC1 | |
| SCHEMBL13680840 | 0.81 | RAB9A (0.41) | ALDH1A1MAPTSMN1; SMN2NPC1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |