Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | NOS2 | P35228 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | CTSA | P10619 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3854280 | 0.85 | MEN1 (0.50) | PDE10ATRPV3ALDH1A1MEN1KMT2A | |
| SCHEMBL13680815 | 0.84 | PDE10A (0.46) | PDE10ASMN1; SMN2ADORA3MAPTALDH1A1 | |
| SCHEMBL13680847 | 0.84 | PDE10A (0.43) | PDE10ATRPV3IRAK4RAB9A | |
| SCHEMBL13680825 | 0.84 | MAPT (0.41) | PDE10ANOS1SMN1; SMN2ADORA3TRPV3 | |
| SCHEMBL13680831 | 0.84 | PDE10A (0.37) | PDE10ASMN1; SMN2TRPV3MAPT | |
| SCHEMBL13680818 | 0.81 | TRPV3 (0.52) | PDE10AADORA3TRPV3 | |
| SCHEMBL13681282 | 0.81 | SCN9A (0.43) | HSD11B1 | |
| SCHEMBL13680830 | 0.81 | RARA (0.44) | PDE10ASMN1; SMN2ALDH1A1KDM4EPOLB | |
| SCHEMBL13680840 | 0.80 | RAB9A (0.41) | SMN1; SMN2MAPTALDH1A1HPGDMEN1 | |
| SCHEMBL13680827 | 0.80 | KMT2A (0.50) | PDE10ASMN1; SMN2MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |