Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.42 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680827 | 0.81 | KMT2A (0.50) | HPGDALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL13680834 | 0.79 | PDE10A (0.39) | HPGDALDH1A1KDM4EMAPTKMT2A | |
| SCHEMBL13680844 | 0.78 | SMN1; SMN2 (0.43) | HPGDALDH1A1KDM4EMAPTNPSR1 | |
| SCHEMBL3854280 | 0.77 | MEN1 (0.50) | ALDH1A1KMT2AMEN1KCNH2 | |
| SCHEMBL13680841 | 0.77 | TSHR (0.40) | KDM4EKMT2AMEN1POLB | |
| SCHEMBL13680948 | 0.76 | SREBF1 (0.51) | HPGDALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL13680831 | 0.76 | PDE10A (0.37) | MAPTSMN1; SMN2 | |
| SCHEMBL13680825 | 0.76 | MAPT (0.41) | HPGDALDH1A1LMNAMAPTKMT2A | |
| SCHEMBL13680815 | 0.76 | PDE10A (0.46) | HPGDALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL12270002 | 0.75 | HPGD (0.57) | HPGDALDH1A1KDM4ELMNAHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |